Cochrane · systematic review · CD008559

Atypical antipsychotics for disruptive behaviour disorders in children and youths

Loy, JH, Merry, SN, Hetrick, SE, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library

Developmental, Psychosocial and Learning Problems2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 40%Moderate 3 · 60%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Risperidone compared to placebo for disruptive behaviours in children and youths

Population: Disruptive behaviours in children and youths

CD008559.PUB3 (current) · 5 questions

Outcome	Effect	Evidence	Status / GRADE
Aggression Risperidone vs placebo	no estimate extracted	3 studies · 238 participants	Low Downgraded: risk of bias, imprecision
Aggression Risperidone vs placebo	no estimate extracted	2 studies · 190 participants	Moderate Downgraded: risk of bias, imprecision, inconsistency
Conduct Risperidone vs placebo	no estimate extracted	2 studies · 225 participants	Moderate Downgraded: risk of bias, imprecision, inconsistency
Weight gain (treatment with antipsychotic only) Risperidone vs placebo	no estimate extracted	2 studies · 138 participants	Moderate Downgraded: risk of bias, imprecision, inconsistency
Weight gain (treatment with antipsychotic and stimulant) Risperidone vs placebo	no estimate extracted	3 studies · 305 participants	Low Downgraded: risk of bias, imprecision, inconsistency

Atypical antipsychotics for disruptive behaviour disorders

Population: children and adolescents with disruptive behaviour disorders

CD008559.PUB2 · 5 questions

Outcome	Effect	Evidence	Status / GRADE
Aggression Aberrant Behaviour Checklist Irritability subscale	no estimate extracted	3 studies · 238 participants	Low Downgraded: risk of bias, imprecision
Aggression Overt Aggression Scale Modified and Overt Aggression Scale	no estimate extracted	2 studies · 57 participants	Low Downgraded: risk of bias, imprecision
Weight gain	no estimate extracted	2 studies · 138 participants	Low Downgraded: risk of bias, imprecision
Conduct problems Nisonger Child Rating Form ‐ Conduct Problem subscale	no estimate extracted	2 studies · 225 participants	Low Downgraded: risk of bias
Conduct problems Conners' Parent Rating Scale ‐ Conduct Problem subscale	no estimate extracted	2 studies · 36 participants	Low Downgraded: risk of bias, imprecision