Cochrane · systematic review · CD008176
Antioxidants for adults with chronic kidney disease
Colombijn, JMT, Hooft, L, Jun, M, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 12.5%Low 1 · 12.5%Moderate 6 · 75%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antioxidants versus control for adults with chronic kidney disease
Population: adults with CKD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cardiovascular death Antioxidants vs control | RR 0.94 [0.64, 1.4] | 8 studies · 3813 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Death (any cause) Antioxidants vs control | RR 0.95 [0.82, 1.11] | 45 studies · 7530 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Cardiovascular disease Antioxidants vs control | RR 0.79 [0.63, 0.99] | 16 studies · 4768 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Heart failure Antioxidants vs control | RR 1.4 [1.11, 1.76] | 6 studies · 3733 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Kidney failure Antioxidants vs control | RR 0.65 [0.41, 1.02] | 10 studies · 3201 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Change in eGFR (mL/min/1.73 m²) Antioxidants vs control | no estimate extracted | 28 studies · 4128 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Graft loss Antioxidants vs control | RR 0.88 [0.67, 1.17] | 11 studies · 1053 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Infection Antioxidants vs control | RR 1.3 [1.14, 1.5] | 14 studies · 3697 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |