Cochrane · systematic review · CD008138
Topical antifungals for seborrhoeic dermatitis
Okokon, EO, Verbeek, JH, Ruotsalainen, JH, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
10
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 30%Low 4 · 40%Moderate 3 · 30%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyKetoconazole compared with placebo for seborrhoeic dermatitis
Population: patients with seborrhoeic dermatitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to achieve complete resolution Clinical assessment Ketoconazole vs placebo | RR 0.69 [0.59, 0.81] | 8 studies · 2520 participants | Low Downgraded: risk of bias, inconsistency |
Side effects Self report Ketoconazole vs placebo | RR 0.97 [0.58, 1.64] | 6 studies · 988 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Ketoconazole compared with steroids for seborrhoeic dermatitis
Population: patients with seborrhoeic dermatitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to achieve complete resolution (combined for face and scalp) Clinical assessment Ketoconazole vs steroids | RR 1.17 [0.95, 1.44] | 6 studies · 302 participants | Low Downgraded: risk of bias, imprecision |
Failure to achieve complete resolution (long term, combined for face and scalp) Clinical assessment Ketoconazole vs steroids | no estimate extracted | 2 studies · 80 participants | Very low Downgraded: risk of bias, inconsistency |
Side effects (combined for face and scalp) Self report Ketoconazole vs steroids | RR 0.56 [0.32, 0.96] | 8 studies · 596 participants | Moderate Downgraded: risk of bias |
Ketoconazole compared with ciclopirox for seborrhoeic dermatitis
Population: patients with seborrhoeic dermatitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to achieve complete resolution ‐ Face only Clinical assessment Ketoconazole vs ciclopirox | RR 1.09 [0.95, 1.26] | 3 studies · 447 participants | Low Downgraded: risk of bias |
Failure to achieve complete resolution (long term) ‐ Face only Clinical assessment Ketoconazole vs ciclopirox | RR 1.16 [0.98, 1.38] | 2 studies · 339 participants | Low Downgraded: risk of bias |
Side effects ‐ Scalp only Self reported Ketoconazole vs ciclopirox | RR 1.35 [0.54, 3.38] | 2 studies · 603 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Ciclopirox compared with placebo for seborrhoeic dermatitis
Population: patients with seborrhoeic dermatitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to achieve complete resolution (combined for face and scalp) Clinical assessment Ciclopirox vs placebo | RR 0.79 [0.67, 0.94] | 8 studies · 1525 participants | Moderate Downgraded: inconsistency |
Side effects (combined for face and scalp) Self reported Ciclopirox vs placebo | RR 0.9 [0.72, 1.11] | 4 studies · 908 participants | Moderate Downgraded: risk of bias |
Ketoconazole compared with placebo for seborrhoeic dermatitis
Population: patients with seborrhoeic dermatitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to achieve complete resolution Clinical assessment Ketoconazole vs placebo | RR 0.69 [0.59, 0.81] | 8 studies · 2520 participants | Low Downgraded: risk of bias, inconsistency |
Side effects Self report Ketoconazole vs placebo | RR 0.97 [0.58, 1.64] | 6 studies · 988 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Ketoconazole compared with steroids for seborrhoeic dermatitis
Population: patients with seborrhoeic dermatitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to achieve complete resolution (combined for face and scalp) Clinical assessment Ketoconazole vs steroids | RR 1.17 [0.95, 1.44] | 6 studies · 302 participants | Low Downgraded: risk of bias, imprecision |
Failure to achieve complete resolution (long term, combined for face and scalp) Clinical assessment Ketoconazole vs steroids | no estimate extracted | 2 studies · 80 participants | Very low Downgraded: risk of bias, inconsistency |
Side effects (combined for face and scalp) Self report Ketoconazole vs steroids | RR 0.56 [0.32, 0.96] | 8 studies · 596 participants | Moderate Downgraded: risk of bias |
Ketoconazole compared with ciclopirox for seborrhoeic dermatitis
Population: patients with seborrhoeic dermatitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to achieve complete resolution ‐ Face only Clinical assessment Ketoconazole vs ciclopirox | RR 1.09 [0.95, 1.26] | 3 studies · 447 participants | Low Downgraded: risk of bias |
Failure to achieve complete resolution (long term) ‐ Face only Clinical assessment Ketoconazole vs ciclopirox | RR 1.16 [0.98, 1.38] | 2 studies · 339 participants | Low Downgraded: risk of bias |
Side effects ‐ Scalp only Self reported Ketoconazole vs ciclopirox | RR 1.35 [0.54, 3.38] | 2 studies · 603 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Ciclopirox compared with placebo for seborrhoeic dermatitis
Population: patients with seborrhoeic dermatitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to achieve complete resolution (combined for face and scalp) Clinical assessment Ciclopirox vs placebo | RR 0.79 [0.67, 0.94] | 8 studies · 1525 participants | Moderate Downgraded: inconsistency |
Side effects (combined for face and scalp) Self reported Ciclopirox vs placebo | RR 0.9 [0.72, 1.11] | 4 studies · 908 participants | Moderate Downgraded: risk of bias |