Cochrane · systematic review · CD008077
Slow versus fast subcutaneous heparin injections for prevention of bruising and site pain intensity
Mohammady, M, Radmehr, M, Janani, L · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 6 · 85.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlySlow versus fast subcutaneous heparin injection for prevention of bruising and site pain intensity
Population: patients treated with subcutaneous heparin injections
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intensity of injection pain ‐ immediately after injection (VAS 0 to 10 cm) Slow vs fast subcutaneous heparin injection | no estimate extracted | 2 studies · 140 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Intensity of injection pain ‐ 48 hours after injection (VAS 0 to 10 cm) Slow vs fast subcutaneous heparin injection | no estimate extracted | 3 studies · 103 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Bruise size ‐ 48 hours after injection (mm/mm2) Slow vs fast subcutaneous heparin injection | no estimate extracted | 5 studies · 503 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Bruise size ‐ 60 hours after injection (mm2) Slow vs fast subcutaneous heparin injection | no estimate extracted | 2 studies · 84 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Bruise size ‐ 72 hours after injection (mm2) Slow vs fast subcutaneous heparin injection | no estimate extracted | 2 studies · 140 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Bruise incidence ‐ 48 hours after injection Slow vs fast subcutaneous heparin injection | OR 0.39 [0.26, 0.6] | 3 studies · 444 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Bruise incidence ‐ 60 hours after injection Slow vs fast subcutaneous heparin injection | OR 0.25 [0.1, 0.65] | 2 studies · 84 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Slow versus fast subcutaneous heparin injection for prevention of bruising and site pain intensity
Population: patients treated with subcutaneous heparin injections
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intensity of injection pain immediately after injection (VAS 0 to 10 cm) Slow vs fast subcutaneous heparin injection | no estimate extracted | 2 studies · 140 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Intensity of injection pain 48 hours after injection (VAS 0 to 10 cm) Slow vs fast subcutaneous heparin injection | no estimate extracted | 2 studies · 59 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Bruise size 48 hours after injection (mm/mm2) Slow vs fast subcutaneous heparin injection | no estimate extracted | 4 studies · 459 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Haematoma at injection site Slow vs fast subcutaneous heparin injection | no estimate extracted | NR | No studies |
Slow versus fast subcutaneous heparin injection for prevention of bruising and site pain intensity
Population: patients treated with subcutaneous heparin injections
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intensity of injection pain immediately after injection (VAS 0 to 10 cm) Slow vs fast subcutaneous heparin injection | no estimate extracted | 2 studies · 140 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Intensity of injection pain 48 hours after injection (VAS 0 to 10 cm) Slow vs fast subcutaneous heparin injection | no estimate extracted | 2 studies · 59 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Bruise size 48 hours after injection (mm/mm2) Slow vs fast subcutaneous heparin injection | no estimate extracted | 4 studies · 459 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Haematoma at injection site Slow vs fast subcutaneous heparin injection | no estimate extracted | NR | No studies |