Cochrane · systematic review · CD008016
Maintenance treatment with antipsychotic drugs for schizophrenia
Ceraso, A, LIN, JJ, Schneider-Thoma, J, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 1 · 14.3%High 3 · 42.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyMaintenance treatment with antipsychotic drugs versus placebo/no treatment for schizophrenia
Population: schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Relapse: 7 to 12 months Maintenance treatment with antipsychotic drugs vs placebo/no treatment | RR 0.38 [0.32, 0.45] | 30 studies · 4249 participants | High |
Leaving the study early: due to any reason (acceptability of treatment) Maintenance treatment with antipsychotic drugs vs placebo/no treatment | RR 0.54 [0.49, 0.61] | 56 studies · 7001 participants | High |
Service use: number of participants hospitalised Maintenance treatment with antipsychotic drugs vs placebo/no treatment | RR 0.43 [0.32, 0.57] | 21 studies · 3558 participants | High |
Death: due to suicide Maintenance treatment with antipsychotic drugs vs placebo/no treatment | RR 0.6 [0.12, 2.97] | 19 studies · 4634 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Quality of life (various scales; low score=better) Maintenance treatment with antipsychotic drugs vs placebo/no treatment | no estimate extracted | 7 studies · 1573 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Number of participants in employment Maintenance treatment with antipsychotic drugs vs placebo/no treatment | RR 1.08 [0.82, 1.41] | 3 studies · 593 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Social functioning (various scales; low score=better) Maintenance treatment with antipsychotic drugs vs placebo/no treatment | no estimate extracted | 15 studies · 3588 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Maintenance treatment with antipsychotic drugs versus placebo/no treatment for schizophrenia
Population: patients with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Relapse: 7 to 12 months Maintenance treatment with antipsychotic drugs vs placebo/no treatment | RR 0.41 [0.34, 0.49] | 24 studies · 2669 participants | High |
Leaving the study early: due to any reason Maintenance treatment with antipsychotic drugs vs placebo/no treatment | RR 0.53 [0.46, 0.61] | 47 studies · 4718 participants | High |
Service use: Number of participants hospitalised Maintenance treatment with antipsychotic drugs vs placebo/no treatment | RR 0.38 [0.27, 0.55] | 16 studies · 2090 participants | High |
Suicide Maintenance treatment with antipsychotic drugs vs placebo/no treatment | RR 0.34 [0.04, 3.28] | 8 studies · 1941 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Quality of life Maintenance treatment with antipsychotic drugs vs placebo/no treatment | no estimate extracted | 3 studies · 527 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Number of participants employed: 7 to 12 months Maintenance treatment with antipsychotic drugs vs placebo/no treatment | RR 0.96 [0.75, 1.23] | 2 studies · 259 participants | Low Downgraded: risk of bias, imprecision, indirectness, publication bias |