Cochrane · systematic review · CD008013
Antidepressants for functional abdominal pain disorders in children and adolescents
de Bruijn, CM, Rexwinkel, R, Gordon, M, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
2
current version
GRADE rated
2
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyAntidepressant compared to placebo for the treatment of functional abdominal pain disorders in children and adolescents
Population: Children and adolescents with functional abdominal pain disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment success Antidepressant vs placebo | RR 1.17 [0.87, 1.56] | 2 studies · 205 participants | Low Downgraded: imprecision |
Withdrawals due to adverse events Antidepressant vs placebo | RR 3.17 [0.65, 15.33] | 3 studies · 238 participants | Low Downgraded: imprecision |
Comparison
Population: adolescents with newly diagnosed irritable bowel syndrome according to Rome II criteria
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Patients' overall assessment of satisfactory relief [Overall, how do you feel your problem is? Answers: better, same, or worse] [4 weeks] | RR 1.12 [0.77, 1.63] | 90 participants | Low Downgraded: risk of bias |
Quality of life [IBS ‐ QOL Questionnaire] 13 weeks | no estimate extracted | 33 participants | Low Downgraded: risk of bias |
Adverse events [methods of adverse effects assessment not reported] | RR 1.91 [0.18, 20.35] | 90 participants | Very low Downgraded: risk of bias |