Cochrane · systematic review · CD007920

Anti‐vascular endothelial growth factor for neovascular glaucoma

Rittiphairoj, T, Roberti, G, Michelessi, M · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library

Eyes and Vision2 versionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
4
No studies
1
Included studies
NR
No studies 1 · 16.7%Ungraded 1 · 16.7%Very low 2 · 33.3%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

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Anti‐VEGF versus no anti‐VEGF for neovascular glaucoma

Population: people with neovascular glaucoma
6 questions
OutcomeEffectEvidenceStatus / GRADE
Proportion of participants with IOP ≤ 21 mmHg, with or without ocular hypotensive medications, 4 to 6 weeks
Anti‐VEGF vs no anti‐VEGF
RR 1.32 [1.1, 1.59]1 study · 93 participantsLow
Downgraded: risk of bias, imprecision
Mean IOP, 4 to 6 weeks
Anti‐VEGF vs no anti‐VEGF
no estimate extracted3 studies · 173 participantsVery low
Downgraded: risk of bias, imprecision
Proportion of participants with improvement in visual acuity of 2 ETDRS lines or 0.2 logMAR units, 4 to 6 weeks
Anti‐VEGF vs no anti‐VEGF
RR 2.55 [1.6, 4.08]1 study · 93 participantsVery low
Downgraded: risk of bias, imprecision
Proportion of participants with complete regression of new iris vessels, 4 to 6 weeks
Anti‐VEGF vs no anti‐VEGF
RR 2.63 [1.65, 4.18]1 study · 93 participantsLow
Downgraded: risk of bias, imprecision
Proportion of participants with relief of pain and resolution of redness, 1 year
Anti‐VEGF vs no anti‐VEGF
no estimate extractedNRNo studies
Proportion of participants with adverse events at various
Anti‐VEGF vs no anti‐VEGF
no estimate extracted6 participantsUngraded