Cochrane · systematic review · CD007892
Vaginal preparation with antiseptic solution before cesarean section for preventing postoperative infections
Haas, DM, Morgan, S, Contreras, K, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 25%Moderate 3 · 75%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyVaginal preparation with antiseptic solution compared to control (no preparation or saline preparation) for preventing postoperative infections
Population: pregnant women undergoing cesarean section
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Post‐cesarean endometritis Vaginal preparation with antiseptic solution vs control (no preparation or saline preparation) | RR 0.41 [0.29, 0.58] | 20 studies · 6918 participants | Moderate Downgraded: risk of bias, imprecision, publication bias |
Postoperative fever Vaginal preparation with antiseptic solution vs control (no preparation or saline preparation) | RR 0.64 [0.5, 0.82] | 16 studies · 6163 participants | Moderate Downgraded: risk of bias, imprecision, publication bias |
Postoperative wound infection Vaginal preparation with antiseptic solution vs control (no preparation or saline preparation) | RR 0.62 [0.5, 0.77] | 18 studies · 6385 participants | Moderate Downgraded: risk of bias |
Composite wound complication or endometritis Vaginal preparation with antiseptic solution vs control (no preparation or saline preparation) | RR 0.46 [0.26, 0.82] | 2 studies · 499 participants | Low Downgraded: risk of bias, imprecision |
Vaginal preparation with antiseptic solution compared to control (no preparation or saline preparation) for preventing postoperative infections
Population: pregnant women who were about to receive a cesarean delivery. This included women receiving elective, laboring, or urgent cesareans
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Post‐cesarean endometritis Vaginal preparation with antiseptic solution vs control (no preparation or saline preparation) | RR 0.36 [0.2, 0.63] | 10 studies · 3283 participants | Moderate |
Postoperative fever Vaginal preparation with antiseptic solution vs control (no preparation or saline preparation) | RR 0.87 [0.72, 1.05] | 8 studies · 3109 participants | Moderate Downgraded: imprecision |
Postoperative wound infection Vaginal preparation with antiseptic solution vs control (no preparation or saline preparation) | RR 0.74 [0.49, 1.11] | 8 studies · 2839 participants | Moderate Downgraded: imprecision |
Composite wound complication or endometritis Vaginal preparation with antiseptic solution vs control (no preparation or saline preparation) | RR 0.46 [0.26, 0.82] | 2 studies · 499 participants | Moderate |
Vaginal preparation versus control for preventing postoperative infections
Population: Pregnant women who received a cesarean delivery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Post‐cesarean endometritis Vaginal preparation vs control | RR 0.45 [0.25, 0.81] | 7 studies · 2635 participants | Low Downgraded: inconsistency |
Postoperative fever Vaginal preparation vs control | RR 0.9 [0.74, 1.1] | 6 studies · 2475 participants | Moderate |
Wound infection Vaginal preparation vs control | RR 0.86 [0.54, 1.36] | 6 studies · 2205 participants | Low Downgraded: imprecision |
Vaginal preparation versus control for preventing postoperative infections
Population: Pregnant women who received a cesarean delivery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Post‐cesarean endometritis Vaginal preparation vs control | RR 0.39 [0.16, 0.97] | 5 studies · 1766 participants | Low Downgraded: imprecision, inconsistency |
Postoperative fever Vaginal preparation vs control | RR 0.92 [0.71, 1.18] | 4 studies · 1606 participants | Moderate Downgraded: imprecision |
Wound infection Vaginal preparation vs control | RR 0.99 [0.57, 1.7] | 4 studies · 1336 participants | Low Downgraded: imprecision |