Cochrane · systematic review · CD007719
Routine vitamin A supplementation for the prevention of blindness due to measles infection in children
Bello, S, Meremikwu, MM, Ejemot‐Nwadiaro, RI, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 14.3%Very low 0 · 0%Low 0 · 0%Moderate 6 · 85.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyComparison
Population: children with measles infection and no clinically demonstrable vitamin A deficiency
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Blindness | no estimate extracted | 2 studies · 260 participants | Ungraded |
Serum retinol (1 week post‐intervention) (mean X (µg/dL) ± standard error (SE) | no estimate extracted | 1 study · 17 participants | Moderate Downgraded: imprecision |
Serum retinol (2 weeks post‐intervention) (mean X (µg/dL) ± standard error SE) | no estimate extracted | 1 study · 155 participants | Moderate Downgraded: imprecision |
Serum retinol (6 weeks post‐intervention) (mean X (µg/dL) ± standard error SE) | no estimate extracted | 1 study · 39 participants | Moderate Downgraded: imprecision |
Serum retinol (mean change 1 week post‐intervention) (mean X (µg/dL) ± standard error SE) | no estimate extracted | 1 study · 17 participants | Moderate Downgraded: imprecision |
Weight gain 6 weeks post‐intervention (mean X (kg) ± standard error SE) | no estimate extracted | 1 study · 48 participants | Moderate Downgraded: imprecision |
Weight gain 6 months post‐intervention (mean X (kg) ± standard error SE) | no estimate extracted | 1 study · 36 participants | Moderate Downgraded: imprecision |
Comparison
Population: children with measles infection and no clinically demonstrable vitamin A deficiency
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Blindness | no estimate extracted | 2 studies · 260 participants | Ungraded |
Serum retinol (1 week post‐intervention) (mean X (µG/dL) ± standard error (SE) | no estimate extracted | 1 study · 17 participants | Moderate Downgraded: imprecision |
Serum retinol (2 weeks post‐intervention) (mean X (µG/dL) ± standard error SE) | no estimate extracted | 1 study · 155 participants | Moderate Downgraded: imprecision |
Serum retinol (6 weeks post‐intervention) (mean X (µG/dL) ± standard error SE) | no estimate extracted | 1 study · 39 participants | Moderate Downgraded: imprecision |
Serum retinol (mean change 1 week post‐intervention (mean X (µG/dL) ± standard error SE) | no estimate extracted | 1 study · 17 participants | Moderate Downgraded: imprecision |
Weight gain 6 weeks post‐intervention (mean X (kg) ± standard error SE) | no estimate extracted | 1 study · 48 participants | Moderate Downgraded: imprecision |
Weight gain 6 months post‐intervention (mean X (kg) ± standard error SE) | no estimate extracted | 1 study · 36 participants | Moderate Downgraded: imprecision |
Other ocular morbidities (night blindness, conjunctival xerosis, Bitot's spot, corneal xerosis, xerophthalmia, corneal ulceration, corneal scars) | no estimate extracted | 2 studies · 260 participants | Ungraded |
Adverse events | no estimate extracted | 2 studies · 260 participants | Ungraded |
Comparison
Population: children with measles infection and no clinically demonstrable vitamin A deficiency
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Blindness | no estimate extracted | 2 studies · 260 participants | Ungraded |
Serum retinol (1 week post‐intervention) (mean X [µg/dL] ± standard error SE) | no estimate extracted | 1 study · 17 participants | Moderate Downgraded: imprecision |
Serum retinol (2 weeks post‐intervention) (mean X [µg/dL] ± standard error SE) | no estimate extracted | 1 study · 155 participants | Moderate Downgraded: imprecision |
Serum retinol (6 weeks post‐intervention) (mean X [µg/dL] ± standard error SE) | no estimate extracted | 1 study · 39 participants | Moderate Downgraded: imprecision |
Serum retinol (mean change 1 week post‐intervention (mean X [µg/dL] ± standard error SE) | no estimate extracted | 1 study · 17 participants | Moderate Downgraded: imprecision |
Weight gain 6 weeks post‐intervention (mean X [kg] ± standard error SE) | no estimate extracted | 1 study · 48 participants | Moderate Downgraded: imprecision |
Weight gain 6 months post‐intervention (mean X [kg] ± standard error SE) | no estimate extracted | 1 study · 36 participants | Moderate Downgraded: imprecision |
Other ocular morbidities (night blindness, conjunctival xerosis, Bitot's spot, corneal xerosis, xerophthalmia, corneal ulceration, corneal scars) | no estimate extracted | 2 studies · 260 participants | Ungraded |
Adverse events | no estimate extracted | 2 studies · 260 participants | Ungraded |