Cochrane · systematic review · CD007699
Warfarin initiation nomograms for venous thromboembolism
Garcia, P, Ruiz, W, Loza Munárriz, C · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 20%Low 2 · 40%Moderate 2 · 40%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version only10 mg warfarin nomogram compared to 5 mg warfarin nomogram for venous thromboembolism
Population: patients with venous thromboembolism.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Therapeutic INR INR TEST 10 mg warfarin nomogram vs 5 mg warfarin nomogram | RR 1.27 [1.05, 1.54] | 3 studies · 383 participants | Moderate Downgraded: inconsistency, indirectness |
Recurrent venous thromboembolism sonography or lung scan or chest computed tomography 10 mg warfarin nomogram vs 5 mg warfarin nomogram | RR 1.48 [0.39, 5.56] | 3 studies · 362 participants | Low Downgraded: inconsistency |
Major bleeding fall in hemoglobin of > 20 g/L or transfusion of 2 or more units of red cells 10 mg warfarin nomogram vs 5 mg warfarin nomogram | RR 0.97 [0.27, 3.51] | 4 studies · 494 participants | Moderate |
Minor bleeding it is not major bleeding 10 mg warfarin nomogram vs 5 mg warfarin nomogram | RR 0.52 [0.15, 1.83] | 2 studies · 243 participants | Very low Downgraded: imprecision, inconsistency |
Length of hospital stay record of hospitalization 10 mg warfarin nomogram vs 5 mg warfarin nomogram | no estimate extracted | 1 study · 111 participants | Low Downgraded: imprecision |
10 mg warfarin nomogram compared to 5 mg warfarin nomogram for venous thromboembolism
Population: patients with venous thromboembolism.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Therapeutic INR INR TEST 10 mg warfarin nomogram vs 5 mg warfarin nomogram | RR 1.27 [1.05, 1.54] | 3 studies · 383 participants | Moderate Downgraded: inconsistency, indirectness |
Recurrent venous thromboembolism sonography or lung scan or chest computed tomography 10 mg warfarin nomogram vs 5 mg warfarin nomogram | RR 1.48 [0.39, 5.56] | 3 studies · 362 participants | Low Downgraded: inconsistency |
Major bleeding fall in hemoglobin of > 20 g/L or transfusion of 2 or more units of red cells 10 mg warfarin nomogram vs 5 mg warfarin nomogram | RR 0.97 [0.27, 3.51] | 4 studies · 494 participants | Moderate |
Minor bleeding it is not major bleeding 10 mg warfarin nomogram vs 5 mg warfarin nomogram | RR 0.52 [0.15, 1.83] | 2 studies · 243 participants | Very low Downgraded: imprecision, inconsistency |
Length of hospital stay record of hospitalization 10 mg warfarin nomogram vs 5 mg warfarin nomogram | no estimate extracted | 1 study · 111 participants | Low Downgraded: imprecision |