Cochrane · systematic review · CD007606

Glucocorticosteroid‐free versus glucocorticosteroid‐containing immunosuppression for liver transplanted patients

Fairfield, C, Penninga, L, Powell, J, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library

Hepato-Biliary2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 1 · 20%Ungraded 0 · 0%Very low 1 · 20%Low 3 · 60%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Show all 2 versions

Glucocorticosteroid avoidance or withdrawal compared to glucocorticosteroid‐based immunosuppression for liver transplanted patients

Population: liver transplanted patients

5 questions

Outcome	Effect	Evidence	Status / GRADE
Outcomes** Glucocorticosteroid avoidance or withdrawal vs glucocorticosteroid‐based immunosuppression	no estimate extracted	NR	No studies
All‐cause mortality Glucocorticosteroid avoidance or withdrawal vs glucocorticosteroid‐based immunosuppression	RR 1.15 [0.93, 1.44]	15 studies · 1323 participants	Low Downgraded: risk of bias, imprecision
Graft loss including death Glucocorticosteroid avoidance or withdrawal vs glucocorticosteroid‐based immunosuppression	RR 1.15 [0.9, 1.46]	11 studies · 1002 participants	Low Downgraded: risk of bias, imprecision
Acute rejection Glucocorticosteroid avoidance or withdrawal vs glucocorticosteroid‐based immunosuppression	RR 1.33 [1.08, 1.64]	16 studies · 1347 participants	Low Downgraded: risk of bias, imprecision
Infection Glucocorticosteroid avoidance or withdrawal vs glucocorticosteroid‐based immunosuppression	RR 0.88 [0.73, 1.05]	8 studies · 778 participants	Very low Downgraded: risk of bias, imprecision, inconsistency