Cochrane · systematic review · CD007498
Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections
Schuetz, P, Wirz, Y, Sager, R, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 50%High 2 · 50%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyProcalcitonin algorithm compared to standard care for guiding antibiotic therapy in acute respiratory tract infections
Population: people with acute respiratory tract infections
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Procalcitonin algorithm vs standard care | OR 0.83 [0.7, 0.99] | 26 studies · 6708 participants | High |
Treatment failure Clinical assessment3 Procalcitonin algorithm vs standard care | OR 0.9 [0.8, 1.01] | 26 studies · 6708 participants | Moderate Downgraded: inconsistency |
Antibiotic‐related side effects Procalcitonin algorithm vs standard care | OR 0.68 [0.57, 0.82] | 6 studies · 3034 participants | Moderate |
Antibiotic exposure Total days of antibiotic therapy in all randomised participants Procalcitonin algorithm vs standard care | no estimate extracted | 26 studies · 6708 participants | High |
Procalcitonin algorithm compared to standard care for guiding antibiotic therapy in acute respiratory tract infections
Population: patients with acute respiratory tract infections
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Procalcitonin algorithm vs standard care | OR 0.91 [0.7, 1.19] | 14 studies · 4211 participants | Moderate Downgraded: risk of bias, imprecision |
Treatment failure Clinical assessment3 Procalcitonin algorithm vs standard care | OR 0.83 [0.71, 0.97] | 14 studies · 4211 participants | Moderate Downgraded: risk of bias |
Antibiotic exposure Total days of antibiotic therapy in all randomised patients Procalcitonin algorithm vs standard care | no estimate extracted | 14 studies · 4211 participants | Moderate Downgraded: risk of bias |