evidencegaps
Cochrane · systematic review · CD007435

Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension

Ho, MJ, Li, ECK, Wright, JM · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library

Hypertension2 versionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
3
current version
GRADE rated
2
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 33.3%Very low 0 · 0%Low 0 · 0%Moderate 2 · 66.7%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Comparison

Population: patients with primary hypertension
CD007435.PUB3 (current) · 3 questions
OutcomeEffectEvidenceStatus / GRADE
End of treatment SBP (over 12 weeks)
no estimate extracted2 studies · 50 participantsModerate
Downgraded: imprecision
End of treatment DBP (over 12 weeks)
no estimate extracted2 studies · 50 participantsModerate
Downgraded: imprecision
Withdrawals due to adverse effects
no estimate extracted1 study · 30 participantsUngraded

Coenzyme Q10 versus placebo in patients with essential arterial hypertension

Population: patients with essential arterial hypertension (SBP > 140 mmHg or DBP > 90 mmHg)
CD007435.PUB2 · 4 questions
OutcomeEffectEvidenceStatus / GRADE
Systolic blood pressure (SBP)
Coenzyme Q10 vs placebo
no estimate extracted3 studies · 96 participantsLow
Diastolic blood pressure (DBP)
Coenzyme Q10 vs placebo
no estimate extracted3 studies · 96 participantsLow
Change in heart rate (HR)
Coenzyme Q10 vs placebo
no estimate extracted1 study · 58 participantsLow
Number of withdrawals due to adverse effects compared to placebo
Coenzyme Q10 vs placebo
no estimate extracted1999 participantsUngraded