Cochrane · systematic review · CD007371

Padma 28 for intermittent claudication

Stewart, M, Morling, JR, Maxwell, H · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library

VascularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 16.7%Very low 4 · 66.7%Low 1 · 16.7%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Padma 28 versus placebo

Population: people with symptomatic intermittent claudication
6 questions
OutcomeEffectEvidenceStatus / GRADE
Pain free walking distance (PFWD)
Padma 28 vs placebo
no estimate extracted2 studies · 79 participantsUngraded
Change in maximum walking distance (MWD)
Padma 28 vs placebo
no estimate extracted1 study · 100 participantsLow
Downgraded: imprecision, inconsistency, publication bias
Final value MWD
Padma 28 vs placebo
no estimate extracted2 studies · 193 participantsVery low
Downgraded: imprecision, publication bias
Adverse effects
Padma 28 vs placebo
OR 1.09 [0.42, 2.83]4 studies · 231 participantsVery low
Downgraded: imprecision, publication bias
Final value ankle brachial index (ABI)
Padma 28 vs placebo
no estimate extracted1 study · 56 participantsVery low
Downgraded: imprecision, inconsistency, publication bias
Change in ABI
Padma 28 vs placebo
no estimate extracted1 study · 56 participantsVery low
Downgraded: imprecision, inconsistency, publication bias