Cochrane · systematic review · CD007346
Safety of topical corticosteroids in pregnancy
Chi, CC, Wang, SH, Wojnarowska, F, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
19
current version
GRADE rated
19
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 10.5%Low 17 · 89.5%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyTopical corticosteroids compared with no topical corticosteroids for pregnant women
Population: pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mode of delivery (risk for either assisted or cesarean delivery) Topical corticosteroids vs no topical corticosteroids | RR 1.04 | 9904 participants | Low Downgraded: imprecision, inconsistency |
Congenital abnormality Topical corticosteroids vs no topical corticosteroids | RR 0.82 | 9433 participants | Low Downgraded: imprecision, inconsistency |
Orofacial cleft Topical corticosteroids vs no topical corticosteroids | RR 1.12 | 40605 participants | Low Downgraded: imprecision, inconsistency |
Low birth weight Topical corticosteroids vs no topical corticosteroids | RR 1.08 | 59419 participants | Very low Downgraded: imprecision, inconsistency |
Preterm delivery Topical corticosteroids vs no topical corticosteroids | RR 0.93 | 59419 participants | Low Downgraded: imprecision, inconsistency |
Foetal death Topical corticosteroids vs no topical corticosteroids | RR 1.02 | 63885 participants | Very low Downgraded: imprecision, inconsistency |
Low Apgar score Topical corticosteroids vs no topical corticosteroids | RR 0.84 | 9220 participants | Low Downgraded: imprecision, inconsistency |
Mild/moderate topical corticosteroids versus no topical corticosteroids for pregnant women
Population: pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Congenital abnormality Mild/moderate topical corticosteroids vs no topical corticosteroids | RR 0.93 | 9263 participants | Low |
Orofacial cleft Mild/moderate topical corticosteroids vs no topical corticosteroids | RR 0.95 | 38446 participants | Low |
Low birth weight Mild/moderate topical corticosteroids vs no topical corticosteroids | RR 0.9 | 55713 participants | Low |
Preterm delivery Mild/moderate topical corticosteroids vs no topical corticosteroids | RR 0.88 | 55713 participants | Low |
Foetal death Mild/moderate topical corticosteroids vs no topical corticosteroids | RR 0.7 | 48749 participants | Low |
Low Apgar score Mild/moderate topical corticosteroids vs no topical corticosteroids | RR 0.73 | 8756 participants | Low |
Potent/very potent topical corticosteroids compared with no topical corticosteroids for pregnant women
Population: pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Congenital abnormality Potent/very potent topical corticosteroids vs no topical corticosteroids | RR 0.56 | 9342 participants | Low |
Orofacial cleft Potent/very potent topical corticosteroids vs no topical corticosteroids | RR 1.5 | 36348 participants | Low |
Low birth weight Potent/very potent topical corticosteroids vs no topical corticosteroids | RR 1.58 | 47651 participants | Low |
Preterm delivery Potent/very potent topical corticosteroids vs no topical corticosteroids | RR 1.05 | 47651 participants | Low |
Foetal death Potent/very potent topical corticosteroids vs no topical corticosteroids | RR 1.14 | 37086 participants | Low |
Low Apgar score Potent/very potent topical corticosteroids vs no topical corticosteroids | RR 1.03 | 7514 participants | Low |
Comparison
Population: pregnant women with skin conditions requiring topical corticosteroids
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mode of delivery | no estimate extracted | 79 participants | Very low |
Congenital abnormality | RR 0.82 [0.34, 1.96] | 9512 participants | Low |
Orofacial cleft | no estimate extracted | 588129 participants | Very low |
Cleft lip ± palate | no estimate extracted | 53468 participants | Very low |
Cleft palate alone | no estimate extracted | 51928 participants | Very low |
Low birthweight | no estimate extracted | 9705 participants | Very low |
Preterm delivery | no estimate extracted | 9705 participants | Very low |
Stillbirth | RR 2.64 [0.81, 8.63] | 9705 participants | Very low |
Low Apgar score | no estimate extracted | 79 participants | Very low |