Cochrane · systematic review · CD007286
Antiepileptic drugs as prophylaxis for postcraniotomy seizures
Greenhalgh, J, Weston, J, Dundar, Y, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
4
No studies
1
Included studies
NR
No studies 1 · 20%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 80%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyAntiepileptic drugs as prophylaxis for postcraniotomy seizures
Population: people with postcraniotomy seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Early seizures(number of people with seizures) | no estimate extracted | 9 studies · 1539 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Late seizures(number of people with seizures) | no estimate extracted | 5 studies · 798 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Death (number of deaths) | no estimate extracted | 5 studies · 1016 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Functional outcome (number of people with disabilities) | no estimate extracted | NR | No studies |
Adverse effects (number of people with adverse events) | no estimate extracted | 8 studies · 1165 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Antiepileptic drugs as prophylaxis for postcraniotomy seizures
Population: people with postcraniotomy seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Early seizures (number of people with seizures) | no estimate extracted | 9 studies · 1539 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Late seizures (number of people with seizures) | no estimate extracted | 5 studies · 798 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Death (number of deaths) | no estimate extracted | 5 studies · 1016 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Functional outcome (number of people with disabilities) | no estimate extracted | NR | No studies |
Adverse effects (number of people with adverse events) | no estimate extracted | 8 studies · 1165 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Antiepileptic drugs as prophylaxis for post‐craniotomy seizures
Population: patients with post‐craniotomy seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Early seizures (number of seizures) | no estimate extracted | 7 studies · 1115 participants | Low Downgraded: risk of bias, imprecision |
Late seizures (number of seizures) | no estimate extracted | 6 studies · 1121 participants | Low Downgraded: risk of bias, imprecision |
Death (number of deaths) | no estimate extracted | 5 studies · 1016 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects (number of events) | no estimate extracted | 6 studies · 926 participants | Low Downgraded: risk of bias, imprecision |
Antiepileptic drugs as prophylaxis for post‐craniotomy seizures
Population: patients with post‐craniotomy seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Early seizures (number of seizures) | no estimate extracted | 5 studies · 911 participants | Low Downgraded: risk of bias, imprecision |
Late seizures (number of seizures) | no estimate extracted | 5 studies · 998 participants | Low Downgraded: risk of bias, imprecision |
Death (number of deaths) | no estimate extracted | 4 studies · 935 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects (number of events) | no estimate extracted | 4 studies · 722 participants | Low Downgraded: risk of bias, imprecision |