Cochrane · systematic review · CD007223
Medical treatments for incomplete miscarriage
Kim, C, Barnard, S, Neilson, JP, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
10
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 4 · 28.6%Very low 3 · 21.4%Low 4 · 28.6%Moderate 3 · 21.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyMisoprostol compared to expectant care for incomplete miscarriage
Population: incomplete miscarriage
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete miscarriage Misoprostol vs expectant care | RR 1.23 [0.72, 2.1] | 2 studies · 150 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Surgical evacuation Misoprostol vs expectant care | RR 0.62 [0.17, 2.26] | 2 studies · 308 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Unplanned surgical intervention Misoprostol vs expectant care | RR 0.62 [0.17, 2.26] | 2 studies · 308 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Women's views/acceptability of method Misoprostol vs expectant care | no estimate extracted | 0 studies · 0 participants | Ungraded |
Nausea Misoprostol vs expectant care | no estimate extracted | 0 studies · 0 participants | Ungraded |
Vomiting Misoprostol vs expectant care | no estimate extracted | 0 studies · 0 participants | Ungraded |
Diarrhoea Misoprostol vs expectant care | no estimate extracted | 0 studies · 0 participants | Ungraded |
Misoprostol compared to surgery for incomplete miscarriage
Population: incomplete miscarriage
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete miscarriage Misoprostol vs surgery | RR 0.96 [0.94, 0.98] | 15 studies · 3862 participants | Very low Downgraded: risk of bias, inconsistency |
Surgical evacuation Misoprostol vs surgery | RR 0.05 [0.02, 0.11] | 13 studies · 3070 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Unplanned surgical intervention Misoprostol vs surgery | RR 5.03 [2.71, 9.35] | 11 studies · 2690 participants | Low Downgraded: risk of bias |
Women's views/acceptability of method Misoprostol vs surgery | RR 1 [0.99, 1] | 9 studies · 3349 participants | Moderate Downgraded: risk of bias |
Nausea Misoprostol vs surgery | RR 2.5 [1.53, 4.09] | 11 studies · 3015 participants | Low Downgraded: risk of bias, inconsistency |
Vomiting Misoprostol vs surgery | RR 1.97 [1.36, 2.85] | 10 studies · 2977 participants | Moderate Downgraded: risk of bias |
Diarrhoea Misoprostol vs surgery | RR 4.82 [1.09, 21.32] | 4 studies · 757 participants | Moderate Downgraded: risk of bias |
Misoprostol versus expectant care for incomplete miscarriage
Population: Women with incomplete miscarriage
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete miscarriage Misoprostol vs expectant care | RR 1.23 [0.72, 2.1] | 2 studies · 150 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Surgical evacuation Misoprostol vs expectant care | RR 0.62 [0.17, 2.26] | 2 studies · 308 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Misoprostol versus surgery for incomplete miscarriage
Population: Women with incomplete miscarriage
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete miscarriage Misoprostol vs surgery | RR 0.97 [0.95, 0.99] | 11 studies · 2493 participants | Low Downgraded: inconsistency |
Surgical evacuation Misoprostol vs surgery | RR 0.06 [0.02, 0.13] | 11 studies · 2654 participants | Low Downgraded: inconsistency |
Unplanned surgical intervention Misoprostol vs surgery | RR 5.82 [2.93, 11.56] | 9 studies · 2274 participants | Moderate |
Nausea Misoprostol vs surgery | RR 2.41 [1.44, 4.03] | 9 studies · 2179 participants | Moderate |
Vomiting Misoprostol vs surgery | RR 1.96 [1.3, 2.95] | 8 studies · 2141 participants | Moderate |
Diarrhoea Misoprostol vs surgery | RR 4.25 [0.76, 23.73] | 3 studies · 437 participants | Moderate |