Cochrane · systematic review · CD007102
First‐line chemotherapy in low‐risk gestational trophoblastic neoplasia
Lawrie, TA, Alazzam, M, Tidy, J, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 40%Moderate 3 · 60%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyComparison
Population: women withe low‐risk GTN
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Primary cure (remission) | RR 0.65 [0.57, 0.75] | 6 studies · 577 participants | Moderate Downgraded: inconsistency |
Failure of first‐line therapy | RR 3.55 [1.81, 6.95] | 6 studies · 577 participants | Moderate Downgraded: inconsistency |
Severe adverse events (≥ grade 3) | RR 0.35 [0.08, 1.66] | 5 studies · 515 participants | Low Downgraded: inconsistency |
Nausea | RR 0.61 [0.29, 1.26] | 4 studies · 466 participants | Moderate Downgraded: inconsistency |
Alopecia | no estimate extracted | NR | Low Downgraded: inconsistency |
Comparison
Population: women withe low‐risk GTN
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Primary cure (remission) | RR 0.64 [0.54, 0.76] | 5 studies · 513 participants | Moderate |
Failure of first‐linetherapy | RR 3.81 [1.64, 8.86] | 5 studies · 513 participants | Moderate |
Severe adverse events (≥ grade 3) | RR 0.35 [0.08, 1.66] | 5 studies · 515 participants | Low |
Nausea | RR 0.61 [0.29, 1.26] | 4 studies · 466 participants | Moderate |
Alopecia | no estimate extracted | NR | Low |