Cochrane · systematic review · CD007022
Teicoplanin versus vancomycin for proven or suspected infection
Cavalcanti, AB, Goncalves, AR, Almeida, CS, et al. · Cochrane Database of Systematic Reviews · 2010 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 14.3%Very low 1 · 14.3%Low 1 · 14.3%Moderate 4 · 57.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Teicoplanin versus vancomycin for proven or suspected infection
Population: patients with proven or suspected infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Nephrotoxicity Teicoplanin vs vancomycin | RR 0.66 [0.48, 0.9] | 23 studies · 2596 participants | Moderate Downgraded: risk of bias |
Clinical cure or improvement Teicoplanin vs vancomycin | RR 1.03 [0.98, 1.08] | 20 studies · 1703 participants | Moderate Downgraded: risk of bias |
Microbiological cure Teicoplanin vs vancomycin | RR 0.98 [0.93, 1.03] | 16 studies · 914 participants | Moderate Downgraded: risk of bias |
Renal failure needing dialysis2 Teicoplanin vs vancomycin | no estimate extracted | 3 studies · 606 participants | Ungraded |
Mortality Teicoplanin vs vancomycin | RR 1.02 [0.79, 1.3] | 16 studies · 1565 participants | Low |
Cutaneous rash Teicoplanin vs vancomycin | RR 0.57 [0.35, 0.92] | 18 studies · 1823 participants | Moderate Downgraded: risk of bias |
Total adverse events Teicoplanin vs vancomycin | RR 0.56 [0.33, 0.95] | 11 studies · 880 participants | Very low Downgraded: risk of bias, inconsistency |