Cochrane · systematic review · CD006915
Heliox inhalation therapy for bronchiolitis in infants
Liet, JM, Ducruet, T, Gupta, V, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Acute Respiratory InfectionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 33.3%Moderate 3 · 50%High 1 · 16.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: infants with bronchiolitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Need for mechanical ventilation (invasive or not) | RR 0.95 [0.61, 1.49] | 4 studies · 408 participants | High |
Rate of intubation (all reasons) | RR 2.73 [0.96, 7.75] | 4 studies · 408 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Rate of emergency department discharge | RR 0.51 [0.17, 1.55] | 1 study · 69 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Length of treatment | no estimate extracted | 2 studies · 320 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Length of treatment ‐ nCPAP | no estimate extracted | 1 study · 21 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Change in clinical respiratory scores (m‐WCAS) within the first hour after starting heliox treatment | no estimate extracted | 4 studies · 138 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |