Cochrane · systematic review · CD006822
Heliox for croup in children
Moraa, I, Sturman, N, McGuire, TM, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
18
current version
GRADE rated
7
No studies
11
Included studies
NR
No studies 11 · 61.1%Ungraded 0 · 0%Very low 0 · 0%Low 7 · 38.9%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyHeliox compared to oxygen 30% for croup in children
Population: children with croup
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in croup score at 20 minutes Heliox vs oxygen 30% | no estimate extracted | 1 study · 15 participants | Low |
Change in respiratory rate at 20 minutes Heliox vs oxygen 30% | no estimate extracted | 1 study · 15 participants | Low |
Change in heart rate at 20 minutes Heliox vs oxygen 30% | no estimate extracted | 1 study · 15 participants | Low |
Proportion of children hospitalised Heliox vs oxygen 30% | no estimate extracted | NR | No studies |
Duration of hospitalisation Heliox vs oxygen 30% | no estimate extracted | NR | No studies |
Proportion of children intubated Heliox vs oxygen 30% | no estimate extracted | NR | No studies |
Duration of intubation Heliox vs oxygen 30% | no estimate extracted | NR | No studies |
Proportion of children re‐presenting for medical care for ongoing croup symptoms Heliox vs oxygen 30% | no estimate extracted | NR | No studies |
Adverse events Heliox vs oxygen 30% | no estimate extracted | NR | No studies |
Heliox compared to placebo or no treatment for croup in children
Population: children with croup
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in croup score at 60 minutes Heliox vs placebo or no treatment | no estimate extracted | 1 study · 47 participants | Low Downgraded: imprecision |
Change in respiratory rate at 60 minutes Heliox vs placebo or no treatment | no estimate extracted | 1 study · 47 participants | Low Downgraded: imprecision |
Change in heart rate at 60 minutes Heliox vs placebo or no treatment | no estimate extracted | NR | No studies |
Proportion of children hospitalised Heliox vs placebo or no treatment | OR 0.46 [0.04, 5.41] | 1 study · 47 participants | Low Downgraded: imprecision |
Duration of hospitalisation Heliox vs placebo or no treatment | no estimate extracted | NR | No studies |
Proportion of children intubated Heliox vs placebo or no treatment | no estimate extracted | NR | No studies |
Duration of intubation Heliox vs placebo or no treatment | no estimate extracted | NR | No studies |
Proportion of children re‐presenting for medical care for ongoing croup symptoms (return to care) Heliox vs placebo or no treatment | OR 0.95 [0.12, 7.41] | 1 study · 47 participants | Low Downgraded: imprecision |
Adverse events Heliox vs placebo or no treatment | no estimate extracted | NR | No studies |
Heliox compared to oxygen 30% for croup in children
Population: children with croup
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in croup score at 20 minutes Heliox vs oxygen 30% | no estimate extracted | 1 study · 15 participants | Low |
Change in respiratory rate at 20 minutes Heliox vs oxygen 30% | no estimate extracted | 1 study · 15 participants | Low |
Change in heart rate at 20 minutes Heliox vs oxygen 30% | no estimate extracted | 1 study · 15 participants | Low |
Proportion of children hospitalised and duration of hospitalisation ‐ not reported Heliox vs oxygen 30% | no estimate extracted | NR | No studies |
Proportion and duration of intubation ‐ not reported Heliox vs oxygen 30% | no estimate extracted | NR | No studies |
Proprtion of children representing for medical care for ongoing croup symptoms ‐ not reported Heliox vs oxygen 30% | no estimate extracted | NR | No studies |
Adverse events ‐ not reported Heliox vs oxygen 30% | no estimate extracted | NR | No studies |
Heliox compared to placebo or no treatment for croup in children
Population: children with croup
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in croup score at 60 minutes Heliox vs placebo or no treatment | no estimate extracted | 1 study · 47 participants | Low Downgraded: imprecision |
Change in respiratory rate at 60 minutes Heliox vs placebo or no treatment | no estimate extracted | 1 study · 47 participants | Low Downgraded: imprecision |
Change in heart rate at 60 minutes ‐ not reported Heliox vs placebo or no treatment | no estimate extracted | NR | No studies |
Proportion of children hospitalised and duration of hospitalisation Heliox vs placebo or no treatment | OR 0.46 [0.04, 5.41] | 1 study · 47 participants | Low Downgraded: imprecision |
Proportion and duration of intubation ‐ not reported Heliox vs placebo or no treatment | no estimate extracted | NR | No studies |
Proportion of children re‐presenting for medical care for ongoing croup symptoms (return to care) Heliox vs placebo or no treatment | OR 0.95 [0.12, 7.41] | 1 study · 47 participants | Low Downgraded: imprecision |
Adverse events ‐ not reported Heliox vs placebo or no treatment | no estimate extracted | NR | No studies |