Cochrane · systematic review · CD006537
Laser treatment of drusen to prevent progression to advanced age‐related macular degeneration
Virgili, G, Michelessi, M, Parodi, MB, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 1 · 14.3%High 2 · 28.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlySummary of findings table: photocoagulation of drusen versus control
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcomes at two years Summary of findings table: photocoagulation of drusen vs control | no estimate extracted | NR | No studies |
Development of CNV Summary of findings table: photocoagulation of drusen vs control | OR 1.07 [0.79, 1.46] | 11 studies · 2159 participants | High |
Development of geographic atrophy Summary of findings table: photocoagulation of drusen vs control | OR 1.3 [0.38, 4.51] | 2 studies · 148 participants | Low Downgraded: imprecision |
Visual loss of 2‐3+ lines of visual acuity Summary of findings table: photocoagulation of drusen vs control | OR 0.99 [0.81, 1.22] | 9 studies · 2002 participants | Moderate Downgraded: risk of bias |
Loss of ≥ 0.3 log units of contrast sensitivity Summary of findings table: photocoagulation of drusen vs control | OR 0.82 [0.2, 3.31] | 1 study · 82 participants | Low Downgraded: imprecision |
Reading speed in words/minute Summary of findings table: photocoagulation of drusen vs control | no estimate extracted | 1 study · 44 participants | Low Downgraded: imprecision |
Drusen reduction Summary of findings table: photocoagulation of drusen vs control | OR 9.16 [6.28, 13.4] | 3 studies · 570 participants | High |
Summary of findings table: photocoagulation of drusen vs control
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcomes at two years Summary of findings table: photocoagulation of drusen vs control | no estimate extracted | NR | No studies |
Development of CNV Summary of findings table: photocoagulation of drusen vs control | OR 1.04 [0.71, 1.51] | 9 studies · 1767 participants | Moderate Downgraded: risk of bias, imprecision |
Development of geographic atrophy Summary of findings table: photocoagulation of drusen vs control | OR 1.3 [0.38, 4.51] | 1 study · 66 participants | Low |
Visual loss of 2‐3+ lines of visual acuity Summary of findings table: photocoagulation of drusen vs control | OR 0.88 [0.67, 1.14] | 6 studies · 1628 participants | Moderate |
Loss of 0.3 log units or more of contrast sensitivity Summary of findings table: photocoagulation of drusen vs control | OR 0.82 [0.2, 3.31] | 1 study · 82 participants | Low |
Reading speed in words/minute Summary of findings table: photocoagulation of drusen vs control | no estimate extracted | 1 study · 44 participants | Low |
Drusen reduction Summary of findings table: photocoagulation of drusen vs control | OR 10.72 | 2 studies · 195 participants | High |