Cochrane · systematic review · CD006517
Antiretroviral regimens for patients with HIV who fail first‐line antiretroviral therapy
Humphreys, EH, Chang, LW, Harris, J · Cochrane Database of Systematic Reviews · 2010 · Cochrane Library
HIV/AIDSAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
3
No studies
3
Included studies
NR
No studies 3 · 50%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 50%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Lamivudine in second‐line therapy
Population: patients with first‐line ART failure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality ‐ not measured | no estimate extracted | NR | No studies |
Disease progression ‐ not measured | no estimate extracted | NR | No studies |
Severe adverse events | no estimate extracted | 1 study · 131 participants | Low Downgraded: imprecision |
Adherence/tolerability/retention ‐ not reported | no estimate extracted | NR | No studies |
Proportion achieving VL <50 copies/ml | RR 1.29 [0.92, 1.8] | 1 study · 131 participants | Low Downgraded: imprecision |
Change from baseline in CD4 | no estimate extracted | 1 study · 131 participants | Low Downgraded: imprecision |