Cochrane · systematic review · CD006419
Antihelminthics in helminth‐endemic areas: effects on HIV disease progression
Means, AR, Burns, P, Sinclair, D, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 37.5%Low 5 · 62.5%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings for participants with unknown helminth infection status
Population: HIV‐positive people
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Viral load | no estimate extracted | 1 study · 166 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
CD4+ cell count | no estimate extracted | 1 study · 917 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Summary of findings for participants with confirmed helminth infections
Population: HIV‐positive people with proven helminth infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Viral load | no estimate extracted | 4 studies · 445 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
CD4+ cell count | no estimate extracted | 3 studies · 358 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Summary of findings for secondary outcomes
Population: HIV‐positive people
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Iron deficiency (serum ferritin) | no estimate extracted | 1 study · 16 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Anaemia (serum haemoglobin) | no estimate extracted | 1 study · 130 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Mortality | RR 0.77 [0.52, 1.14] | 5 studies · 1627 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Adverse events | RR 1.23 [0.53, 2.83] | 7 studies · 1649 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |