Cochrane · systematic review · CD006401
Statins for children with familial hypercholesterolemia
Vuorio, A, Kuoppala, J, Kovanen, PT, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 71.4%Moderate 1 · 14.3%High 1 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyComparison
Population: children with familial hypercholesterolemia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in carotid intima‐media thickness (mm) ‐ at 2 years | no estimate extracted | 1 study · 211 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Change in serum LDL cholesterol level (%) ‐ at end of | no estimate extracted | 6 studies · 669 participants | High |
Change in measures of growth and maturation: change in puberty proportion with Tanner stage ≧ 1 level ‐ at 2 years | RR 0.95 [0.77, 1.18] | 1 study · 211 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Liver dysfunction: proportion with changed aspartate aminotransferase or alanine aminotransferase levels (> 3x ULN) ‐ at all time points | no estimate extracted | 7 studies · 9244 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Myopathy: proportion with changed serum creatine kinase levels (>10x ULN) ‐ at all time points | no estimate extracted | 6 studies · 6694 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Change in endothelial function: Change in flow‐mediated dilatation of brachial artery (%) | no estimate extracted | 1 study · 50 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Adverse events ‐ at one year | RR 1.01 [0.81, 1.26] | 2 studies · 276 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Comparison
Population: children with familial hypercholesterolemia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in carotid intima‐media thickness (mm) ‐ At 2 years | no estimate extracted | 1 study · 211 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Change in serum LDL cholesterol level (%) ‐ At end of | no estimate extracted | 6 studies · 669 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Change in measures of growth and maturation: change in puberty proportion with Tanner stage ≧ 1 level ‐ At 2 years | RR 0.95 [0.77, 1.18] | 1 study · 211 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Liver dysfunction: proportion with changed aspartate aminotransferase or alanine aminotransferase levels (> 3x ULN) ‐ At all time points | no estimate extracted | 7 studies · 9244 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Myopathy: proportion with changed serum creatine kinase levels (>10x ULN) ‐ At all time points | no estimate extracted | 6 studies · 6694 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Change in endothelial function: Change in flow‐mediated dilatation of brachial artery (%) | no estimate extracted | 1 study · 50 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Adverse events ‐ At one year | RR 1.01 [0.81, 1.26] | 2 studies · 276 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |