Cochrane · systematic review · CD006322
Pulmonary rehabilitation for interstitial lung disease
Dowman, L, Hill, CJ, May, A, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 9 · 64.3%Moderate 5 · 35.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyPulmonary rehabilitation compared to no pulmonary rehabilitation for interstitial lung disease
Population: interstitial lung disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in 6MWD Pulmonary rehabilitation vs no pulmonary rehabilitation | no estimate extracted | 13 studies · 585 participants | Moderate Downgraded: risk of bias |
Change in 6MWD at long‐term Pulmonary rehabilitation vs no pulmonary rehabilitation | no estimate extracted | 6 studies · 321 participants | Moderate Downgraded: risk of bias, imprecision |
Change in peak work capacity Pulmonary rehabilitation vs no pulmonary rehabilitation | no estimate extracted | 4 studies · 159 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Change in dyspnoea score Pulmonary rehabilitation vs no pulmonary rehabilitation | no estimate extracted | 7 studies · 348 participants | Low Downgraded: risk of bias, inconsistency |
Change in quality of life Pulmonary rehabilitation vs no pulmonary rehabilitation | no estimate extracted | 11 studies · 478 participants | Moderate Downgraded: risk of bias |
Change in quality of life at long‐term Pulmonary rehabilitation vs no pulmonary rehabilitation | no estimate extracted | 4 studies · 240 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Long‐term survival (incidence of mortality) Pulmonary rehabilitation vs no pulmonary rehabilitation | OR 0.4 [0.14, 1.12] | 4 studies · 291 participants | Low Downgraded: risk of bias, imprecision |
Pulmonary rehabilitation compared to no pulmonary rehabilitation for idiopathic pulmonary fibrosis
Population: idiopathic pulmonary fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in 6MWD Pulmonary rehabilitation vs no pulmonary rehabilitation | no estimate extracted | 8 studies · 278 participants | Moderate Downgraded: risk of bias |
Change in 6MWD at long‐term Pulmonary rehabilitation vs no pulmonary rehabilitation | no estimate extracted | 3 studies · 123 participants | Low Downgraded: risk of bias, imprecision |
Change in peak work capacity Pulmonary rehabilitation vs no pulmonary rehabilitation | no estimate extracted | 2 studies · 62 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Change in dyspnoea score Pulmonary rehabilitation vs no pulmonary rehabilitation | no estimate extracted | 4 studies · 155 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Change in quality of life Pulmonary rehabilitation vs no pulmonary rehabilitation | no estimate extracted | 6 studies · 194 participants | Moderate Downgraded: risk of bias |
Change in quality of life at long‐term Pulmonary rehabilitation vs no pulmonary rehabilitation | no estimate extracted | 2 studies · 89 participants | Low Downgraded: risk of bias, imprecision |
Long‐term survival (incidence of mortality) Pulmonary rehabilitation vs no pulmonary rehabilitation | OR 0.32 [0.08, 1.19] | 3 studies · 127 participants | Low Downgraded: risk of bias, imprecision |
Pulmonary rehabilitation compared with no pulmonary rehabilitation for interstitial lung disease
Population: people with interstitial lung disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in 6‐minute walk distance 6‐Minute walk test Pulmonary rehabilitation vs no pulmonary rehabilitation | MD 44.34 [26.04, 62.64] | 5 studies · 168 participants | Moderate Downgraded: risk of bias, imprecision |
Change in peak oxygen uptake Cardiopulmonary exercise test Pulmonary rehabilitation vs no pulmonary rehabilitation | MD 1.24 [0.46, 2.13] | 2 studies · 80 participants | Low Downgraded: risk of bias, imprecision |
Change in maximum ventilation Cardiopulmonary exercise test Pulmonary rehabilitation vs no pulmonary rehabilitation | MD 4.71 [0.1, 9.32] | 1 study · 52 participants | Low Downgraded: imprecision |
Change in dyspnoea score Modified Medical Research Council Dyspnoea Scale Pulmonary rehabilitation vs no pulmonary rehabilitation | no estimate extracted | 3 studies · 113 participants | Low Downgraded: risk of bias, imprecision |
Change in quality of life Chronic Respiratory Disease Questionnaire (total score) Pulmonary rehabilitation vs no pulmonary rehabilitation | SMD 0.59 [0.2, 0.98] | 3 studies · 106 participants | Low Downgraded: risk of bias, imprecision |
6‐Month survival Pulmonary rehabilitation vs no pulmonary rehabilitation | RR 0.9 [0.13, 4.77] | 1 study · 57 participants | Low Downgraded: imprecision |
Adverse events Pulmonary rehabilitation vs no pulmonary rehabilitation | no estimate extracted | 2 studies · 85 participants | Ungraded |
Pulmonary rehabilitation compared with no pulmonary rehabilitation for idiopathic pulmonary fibrosis
Population: people with idiopathic pulmonary fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in 6‐minute walk distance 6‐Minute walk test Pulmonary rehabilitation vs no pulmonary rehabilitation | MD 35.63 [16.02, 55.23] | 4 studies · 111 participants | Moderate Downgraded: risk of bias, imprecision |
Change in peak oxygen uptake Cardiopulmonary exercise test Pulmonary rehabilitation vs no pulmonary rehabilitation | MD 1.46 [0.54, 2.39] | 2 studies · 58 participants | Low Downgraded: risk of bias, imprecision |
Change in maximum ventilation Cardiopulmonary exercise test Pulmonary rehabilitation vs no pulmonary rehabilitation | MD 6.97 [0.87, 13.07] | 1 study · 30 participants | Low Downgraded: imprecision |
Change in dyspnoea Modified Medical Research Council Dyspnoea Scale Pulmonary rehabilitation vs no pulmonary rehabilitation | no estimate extracted | 3 studies · 90 participants | Low Downgraded: risk of bias, imprecision |
Change in quality of life Chronic Respiratory Disease Questionnaire (total score) Pulmonary rehabilitation vs no pulmonary rehabilitation | SMD 0.59 [0.14, 1.03] | 3 studies · 83 participants | Low Downgraded: risk of bias, imprecision |
6‐Month survival Pulmonary rehabilitation vs no pulmonary rehabilitation | OR 0.67 [0.08, 5.4] | 1 study · 34 participants | Low Downgraded: imprecision |
Adverse events Pulmonary rehabilitation vs no pulmonary rehabilitation | no estimate extracted | 2 studies · 62 participants | Ungraded |