Cochrane · systematic review · CD006089
Antibiotics for acute rhinosinusitis in adults
Lemiengre, MB, van Driel, ML, Merenstein, D, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 28.6%High 5 · 71.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyAntibiotics compared to placebo for acute rhinosinusitis in adults
Population: acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cure in adults with clinically diagnosed acute rhinosinusitis Antibiotics vs placebo | OR 1.25 [1.02, 1.54] | 8 studies · 1687 participants | High |
Cure in adults with acute rhinosinusitis confirmed by radiography1 Antibiotics vs placebo | OR 1.57 [1.03, 2.39] | 3 studies · 394 participants | Moderate Downgraded: risk of bias, inconsistency |
Cure in adults with acute rhinosinusitis confirmed by computed tomography1,4 Antibiotics vs placebo | OR 4.89 [1.75, 13.72] | 1 study · 127 participants | Moderate Downgraded: risk of bias, inconsistency |
Severity or duration of different clinical symptoms: resolution of purulent secretion Antibiotics vs placebo | OR 1.58 [1.13, 2.22] | 3 studies · 660 participants | High |
Side effects: total Antibiotics vs placebo | OR 2.21 [1.74, 2.82] | 10 studies · 1816 participants | High |
Side effects: diarrhoea Antibiotics vs placebo | Peto OR 2 [1.41, 2.85] | 7 studies · 1210 participants | High |
Clinical failure Antibiotics vs placebo | Peto OR 0.48 [0.36, 0.63] | 12 studies · 2603 participants | High |
Antbiotics compared to placebo for clinically diagnosed acute rhinosinusitis in adults
Population: clinically diagnosed acute rhinosinusitis in adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cure Antbiotics vs placebo | OR 1.25 [1.02, 1.53] | 8 studies · 1687 participants | High |
Resolution of purulent secretion Antbiotics vs placebo | OR 1.58 [1.13, 2.22] | 3 studies · 660 participants | High |
Side effects Antbiotics vs placebo | OR 2.1 [1.6, 2.77] | 7 studies · 1371 participants | High |
Diarrhoea Antbiotics vs placebo | OR 1.81 [1.18, 2.78] | 4 studies · 816 participants | High |
Treatment failure Antbiotics vs placebo | OR 0.49 [0.36, 0.66] | 8 studies · 2175 participants | High |