Cochrane · systematic review · CD006006
Prostaglandins for adult liver transplanted recipients
Mohamed, ZUmer, Varghese, CTitus, Sudhakar, A, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 1 · 14.3%Low 5 · 71.4%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyProstaglandin compared with placebo or standard care for adult liver transplanted recipients
Population: adult liver transplanted recipients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality ( Prostaglandin vs placebo or standard care | RR 0.86 [0.61, 1.23] | 11 studies · 771 participants | Low Downgraded: risk of bias, imprecision |
Serious adverse eventsc ( Prostaglandin vs placebo or standard care | RR 0.92 [0.6, 1.4] | 6 studies · 568 participants | Low Downgraded: risk of bias, imprecision |
Health‐related quality of life Prostaglandin vs placebo or standard care | no estimate extracted | NR | No studies |
Liver retransplantation ( Prostaglandin vs placebo or standard care | RR 0.98 [0.49, 1.96] | 6 studies · 468 participants | Low Downgraded: risk of bias, imprecision |
Primary non‐function of the allograft (at up to 1 month) Prostaglandin vs placebo or standard care | RR 0.58 [0.26, 1.32] | 7 studies · 624 participants | Low Downgraded: risk of bias, imprecision |
Acute kidney failure requiring dialysis ( Prostaglandin vs placebo or standard care | RR 0.42 [0.24, 0.73] | 6 studies · 477 participants | Low Downgraded: risk of bias, imprecision |
Adverse events considered non‐serious ( Prostaglandin vs placebo or standard care | RR 1.19 [0.42, 3.36] | 4 studies · 329 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Prostaglandins for adult liver transplanted patients
Population: patients with adult liver transplanted patients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality | OR 0.84 [0.52, 1.37] | 6 studies · 610 participants | Low Downgraded: risk of bias |
Primary non‐function of the allograft | OR 0.55 [0.23, 1.33] | 4 studies · 488 participants | Low Downgraded: risk of bias |
Liver re‐transplantation | OR 0.99 [0.44, 2.25] | 4 studies · 332 participants | Low Downgraded: risk of bias |
Acute renal failure requiring dialysis | OR 0.37 [0.18, 0.75] | 4 studies · 329 participants | Moderate Downgraded: risk of bias |
Hypotension | OR 0.14 [0.01, 2.78] | 2 studies · 277 participants | Very low Downgraded: risk of bias |