Cochrane · systematic review · CD005982
Low molecular weight heparin for prevention of central venous catheter‐related thrombosis in children
Pelland-Marcotte, M-C, Amiri, N, Avila, ML, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 16.7%Low 5 · 83.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyDoes low molecular weight heparin prevent central venous catheter‐related thrombosis compared to control in children?
Population: children with a CVC
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
CVC‐related thrombosis ( Does low molecular weight heparin prevent central venous catheter‐related thrombosis vs control | RR 0.68 [0.27, 1.75] | 2 studies · 787 participants | Low Downgraded: risk of bias, inconsistency |
Symptomatic CVC‐related thrombosis ( Does low molecular weight heparin prevent central venous catheter‐related thrombosis vs control | RR 1.03 [0.21, 4.93] | 1 study · 158 participants | Low Downgraded: risk of bias, imprecision |
Asymptomatic CVC‐related thrombosis ( Does low molecular weight heparin prevent central venous catheter‐related thrombosis vs control | RR 1.17 [0.45, 3.08] | 1 study · 158 participants | Low Downgraded: risk of bias, imprecision |
Major bleeding ( Does low molecular weight heparin prevent central venous catheter‐related thrombosis vs control | RR 0.27 [0.05, 1.67] | 2 studies · 813 participants | Low Downgraded: risk of bias, imprecision |
Minor bleeding ( Does low molecular weight heparin prevent central venous catheter‐related thrombosis vs control | no estimate extracted | 2 studies · 813 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Mortality during study period ( Does low molecular weight heparin prevent central venous catheter‐related thrombosis vs control | no estimate extracted | 2 studies · 813 participants | Low Downgraded: imprecision, inconsistency |
Low molecular weight heparin for prevention of central venous catheter (CVC)‐related thrombosis in children
Population: Children with central venous catheter
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
CVC‐related symptomatic thrombosis Venography § | RR 1.03 [0.21, 4.93] | 1 study · 158 participants | Low |
CVC‐related asymptomatic thrombosis Venography § | RR 1.17 [0.45, 3.48] | 1 study · 158 participants | Low |
Side effects of LMWH: major bleeding Clinical findings | RR 0.34 [0.01, 8.26] | 1 study · 184 participants | Low |
Side effects of LMWH: minor bleeding Clinical findings | RR 1.2 [0.91, 1.58] | 1 study · 184 participants | Low |
Mortality during period of therapy | no estimate extracted | 1 study · 184 participants | Low |