Cochrane · systematic review · CD005974
Homeopathic medicinal products for preventing and treating acute respiratory tract infections in children
Hawke, K, King, D, van Driel, ML, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
17
current version
GRADE rated
11
No studies
6
Included studies
NR
No studies 6 · 35.3%Ungraded 0 · 0%Very low 3 · 17.6%Low 5 · 29.4%Moderate 3 · 17.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyHomeopathic medicinal products (individualised treatment) compared to placebo or usual care for preventing acute respiratory tract infections in children
Population: children aged up to 16 years with ARTIs
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Disease severity Homeopathic medicinal products (individualised treatment) vs placebo or usual care | no estimate extracted | 2 studies · 369 participants | Low Downgraded: imprecision, inconsistency |
Recurrence of ARTI Homeopathic medicinal products (individualised treatment) vs placebo or usual care | OR 1.31 [0.64, 2.7] | 1 study · 199 participants | Moderate Downgraded: imprecision |
Days off work for parents Homeopathic medicinal products (individualised treatment) vs placebo or usual care | OR 1.46 [0.83, 2.55] | 1 study · 199 participants | Moderate Downgraded: imprecision |
Need for antibiotics Homeopathic medicinal products (individualised treatment) vs placebo or usual care | OR 0.79 [0.35, 1.76] | 2 studies · 369 participants | Low Downgraded: imprecision, inconsistency |
Adverse events Homeopathic medicinal products (individualised treatment) vs placebo or usual care | OR 2.51 [0.75, 8.42] | 1 study · 199 participants | Moderate Downgraded: imprecision |
Homeopathic medicinal products (non‐individualised treatment) compared to placebo or usual care for preventing acute respiratory tract infections in children
Population: children aged up to 16 years with ARTIs
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Disease severity Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Recurrence of ARTI Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | OR 0.6 [0.21, 1.72] | 3 studies · 735 participants | Low Downgraded: risk of bias, imprecision |
Days off work for parents Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Need for antibiotics Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Adverse events Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | OR 0.26 [0.03, 2.43] | 1 study · 95 participants | Very low Downgraded: imprecision, indirectness |
Homeopathic medicinal products compared to placebo or usual care for treating acute respiratory tract infections in children (individualised and non‐individualised studies)
Population: children aged up to 16 years with ARTIs
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Short‐term cure1 Homeopathic medicinal products vs placebo or usual care | OR 1.31 [0.09, 19.54] | 2 studies · 155 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Long‐term cure1 Homeopathic medicinal products vs placebo or usual care | OR 1.01 | 2 studies · 155 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Disease severity( Homeopathic medicinal products vs placebo or usual care | no estimate extracted | 6 studies · 709 participants | Low Downgraded: risk of bias, inconsistency |
Recurrence of ARTI Homeopathic medicinal products vs placebo or usual care | no estimate extracted | NR | No studies |
Days off work for parents Homeopathic medicinal products vs placebo or usual care | no estimate extracted | NR | No studies |
Need for antibiotics Homeopathic medicinal products vs placebo or usual care | no estimate extracted | NR | No studies |
Adverse events Homeopathic medicinal products vs placebo or usual care | no estimate extracted | 1 study · 75 participants | Low Downgraded: risk of bias, imprecision |
Homeopathic medicinal products (individualised treatment) compared to placebo or usual care for preventing acute respiratory tract infections in children
Population: children aged up to 10 years
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Disease severity Homeopathic medicinal products (individualised treatment) vs placebo or usual care | no estimate extracted | 2 studies · 369 participants | Low Downgraded: imprecision, inconsistency |
Reccurrence of ARTI Homeopathic medicinal products (individualised treatment) vs placebo or usual care | OR 1.31 [0.64, 2.7] | 1 study · 199 participants | Moderate Downgraded: imprecision |
Days off work for parents Homeopathic medicinal products (individualised treatment) vs placebo or usual care | OR 1.46 [0.83, 2.55] | 1 study · 199 participants | Moderate Downgraded: imprecision |
Need for antibiotics Homeopathic medicinal products (individualised treatment) vs placebo or usual care | OR 0.79 [0.35, 1.76] | 2 studies · 369 participants | Low Downgraded: imprecision, inconsistency |
Number of courses of antibiotics Homeopathic medicinal products (individualised treatment) vs placebo or usual care | no estimate extracted | 1 study · 170 participants | Moderate Downgraded: risk of bias |
Adverse events Homeopathic medicinal products (individualised treatment) vs placebo or usual care | OR 2.51 [0.75, 8.42] | 1 study · 199 participants | Moderate Downgraded: imprecision |
Duration of illness Homeopathic medicinal products (individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Need for hospitalisation or severe secondary illness Homeopathic medicinal products (individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Quality of life Homeopathic medicinal products (individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Homeopathic medicinal products (non‐individualised treatment) compared to placebo or usual care for preventing acute respiratory tract infections in children
Population: children aged up to 12 years
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Reccurrence of ARTI Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | OR 1.14 [0.83, 1.57] | 2 studies · 695 participants | Low Downgraded: imprecision, indirectness |
Number of ARTIs Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | no estimate extracted | 1 study · 600 participants | Moderate Downgraded: indirectness |
Adverse events Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | OR 0.26 [0.03, 2.43] | 1 study · 95 participants | Very low Downgraded: imprecision, indirectness |
Disease severity Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Days off work for parents Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Duration of illness Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Need for antibiotics Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Number of courses of antibiotics Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Need for hospitalisation or severe secondary illness Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Quality of life Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Homeopathic medicinal products compared to placebo or usual care for treating acute respiratory tract infections in children
Population: children aged between 2 and 6 years with acute respiratory infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Short‐term curea Homeopathic medicinal products vs placebo or usual care | OR 1.31 [0.09, 19.54] | 2 studies · 155 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Long‐term curea Homeopathic medicinal products vs placebo or usual care | OR 0.99 [0.1, 9.67] | 2 studies · 155 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Disease severity Homeopathic medicinal products vs placebo or usual care | no estimate extracted | 4 studies · 339 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Antibiotic use Homeopathic medicinal products vs placebo or usual care | no estimate extracted | 1 study · 40 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse eventsa Homeopathic medicinal products vs placebo or usual care | no estimate extracted | 1 study · 75 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Adverse eventsb Homeopathic medicinal products vs placebo or usual care | OR 3.55 [1.27, 9.96] | 1 study · 249 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Recurrence of ARTI Homeopathic medicinal products vs placebo or usual care | no estimate extracted | NR | No studies |
Duration of illness Homeopathic medicinal products vs placebo or usual care | no estimate extracted | NR | No studies |
Need for hospitalisation or severe secondary illness Homeopathic medicinal products vs placebo or usual care | no estimate extracted | NR | No studies |
Days of school and days off work for parents Homeopathic medicinal products vs placebo or usual care | no estimate extracted | NR | No studies |
Quality of life Homeopathic medicinal products vs placebo or usual care | no estimate extracted | NR | No studies |
Homeopathic medicinal products (individualised treatment) compared to placebo or usual care for preventing acute respiratory tract infections in children
Population: children aged up to 10 years
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Disease severity Homeopathic medicinal products (individualised treatment) vs placebo or usual care | no estimate extracted | 2 studies · 369 participants | Low Downgraded: imprecision, inconsistency |
Reccurrence of ARTI Homeopathic medicinal products (individualised treatment) vs placebo or usual care | OR 1.31 [0.64, 2.7] | 1 study · 199 participants | Moderate Downgraded: imprecision |
Days off work for parents Homeopathic medicinal products (individualised treatment) vs placebo or usual care | OR 1.46 [0.83, 2.55] | 1 study · 199 participants | Moderate Downgraded: imprecision |
Need for antibiotics Homeopathic medicinal products (individualised treatment) vs placebo or usual care | OR 0.79 [0.35, 1.76] | 2 studies · 369 participants | Low Downgraded: imprecision, inconsistency |
Number of courses of antibiotics Homeopathic medicinal products (individualised treatment) vs placebo or usual care | no estimate extracted | 1 study · 170 participants | Moderate Downgraded: risk of bias |
Adverse events Homeopathic medicinal products (individualised treatment) vs placebo or usual care | OR 2.51 [0.75, 8.42] | 1 study · 199 participants | Moderate Downgraded: imprecision |
Duration of illness Homeopathic medicinal products (individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Need for hospitalisation or severe secondary illness Homeopathic medicinal products (individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Quality of life Homeopathic medicinal products (individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Homeopathic medicinal products (non‐individualised treatment) compared to placebo or usual care for preventing acute respiratory tract infections in children
Population: children aged up to 12 years
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Reccurrence of ARTI Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | OR 1.14 [0.83, 1.57] | 2 studies · 695 participants | Low Downgraded: imprecision, indirectness |
Number of ARTIs Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | no estimate extracted | 1 study · 600 participants | Moderate Downgraded: indirectness |
Adverse events Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | OR 0.26 [0.03, 2.43] | 1 study · 95 participants | Very low Downgraded: imprecision, indirectness |
Disease severity Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Days off work for parents Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Duration of illness Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Need for antibiotics Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Number of courses of antibiotics Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Need for hospitalisation or severe secondary illness Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Quality of life Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care | no estimate extracted | NR | No studies |
Homeopathic medicinal products compared to placebo or usual care for treating acute respiratory tract infections in children
Population: children aged between 2 and 6 years with acute respiratory infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Short‐term curea Homeopathic medicinal products vs placebo or usual care | OR 1.31 [0.09, 19.54] | 2 studies · 155 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Long‐term curea Homeopathic medicinal products vs placebo or usual care | OR 1.01 [0.1, 9.96] | 2 studies · 155 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Disease severity Homeopathic medicinal products vs placebo or usual care | no estimate extracted | 4 studies · 339 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Antibiotic use Homeopathic medicinal products vs placebo or usual care | no estimate extracted | 1 study · 40 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse eventsa Homeopathic medicinal products vs placebo or usual care | no estimate extracted | 1 study · 75 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Adverse eventsb Homeopathic medicinal products vs placebo or usual care | OR 3.55 [1.27, 9.96] | 1 study · 249 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Recurrence of ARTI Homeopathic medicinal products vs placebo or usual care | no estimate extracted | NR | No studies |
Duration of illness Homeopathic medicinal products vs placebo or usual care | no estimate extracted | NR | No studies |
Need for hospitalisation or severe secondary illness Homeopathic medicinal products vs placebo or usual care | no estimate extracted | NR | No studies |
Days of school and days off work for parents Homeopathic medicinal products vs placebo or usual care | no estimate extracted | NR | No studies |
Quality of life Homeopathic medicinal products vs placebo or usual care | no estimate extracted | NR | No studies |