Cochrane · systematic review · CD005967
Artesunate versus quinine for treating severe malaria
Sinclair, D, Donegan, S, Isba, R, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
9
No studies
1
Included studies
NR
No studies 1 · 10%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 5 · 50%High 4 · 40%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyComparison
Population: Children with severe malaria
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death | RR 0.76 [0.65, 0.9] | 4 studies · 5765 participants | High |
Neurological sequelae at day 28 | RR 1.23 [0.74, 2.03] | 1 study · 4857 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Neurological sequelae at discharge | RR 1.36 [1.01, 1.83] | 3 studies · 5163 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Time to hospital discharge (days) | no estimate extracted | 3 studies · 113 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Hypoglycaemia episodes | RR 0.62 [0.45, 0.87] | 4 studies · 5765 participants | High |
Comparison
Population: Adults with severe malaria
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death | RR 0.61 [0.5, 0.75] | 5 studies · 1664 participants | High |
Neurological sequelae at day 28 | no estimate extracted | NR | No studies |
Neurological sequelae at discharge | RR 2.97 [0.6, 14.64] | 1 study · 1259 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Time to hospital discharge (days) | no estimate extracted | 2 studies · 113 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Hypoglycaemia episodes | RR 0.36 [0.19, 0.68] | 2 studies · 1372 participants | High |
Comparison
Population: Children with severe malaria
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death | RR 0.76 [0.65, 0.9] | 4 studies · 5765 participants | High |
Neurological sequelae at day 28 | RR 1.23 [0.74, 2.03] | 1 study · 4857 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Neurological sequelae at discharge | RR 1.36 [1.01, 1.83] | 3 studies · 5163 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Time to hospital discharge (days) | no estimate extracted | 3 studies · 113 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Hypoglycaemia episodes | RR 0.62 [0.45, 0.87] | 4 studies · 5765 participants | High |
Comparison
Population: Adults with severe malaria
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death | RR 0.61 [0.5, 0.75] | 5 studies · 1664 participants | High |
Neurological sequelae at day 28 | no estimate extracted | NR | No studies |
Neurological sequelae at discharge | RR 2.97 [0.6, 14.64] | 1 study · 1259 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Time to hospital discharge (days) | no estimate extracted | 2 studies · 113 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Hypoglycaemia episodes | RR 0.36 [0.19, 0.68] | 2 studies · 1372 participants | High |