Cochrane · systematic review · CD005632
Steroid avoidance or withdrawal for kidney transplant recipients
Haller, MC, Royuela, A, Nagler, EV, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
10
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 8 · 80%Moderate 2 · 20%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Steroid withdrawal versus steroid maintenance for kidney transplant recipients
Population: kidney transplant recipients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Steroid withdrawal vs steroid maintenance | RR 0.68 [0.36, 1.3] | 10 studies · 1913 participants | Low Downgraded: risk of bias, imprecision |
Graft loss (excluding death) Steroid withdrawal vs steroid maintenance | RR 1.17 [0.72, 1.92] | 8 studies · 1817 participants | Low Downgraded: risk of bias, imprecision |
Acute rejection Steroid withdrawal vs steroid maintenance | RR 1.77 [1.2, 2.61] | 10 studies · 1913 participants | Moderate Downgraded: risk of bias, imprecision |
NODAT Steroid withdrawal vs steroid maintenance | RR 0.77 [0.49, 1.21] | 6 studies · 1439 participants | Low Downgraded: risk of bias, imprecision |
CMV infection Steroid withdrawal vs steroid maintenance | RR 1.04 [0.8, 1.36] | 5 studies · 1758 participants | Low Downgraded: risk of bias, imprecision |
Steroid avoidance versus steroid maintenance for kidney transplant recipients
Population: kidney transplant recipients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Steroid avoidance vs steroid maintenance | RR 0.96 [0.52, 1.8] | 10 studies · 1462 participants | Low Downgraded: risk of bias, imprecision |
Graft loss (excluding death) Steroid avoidance vs steroid maintenance | RR 1.09 [0.64, 1.86] | 7 studies · 1211 participants | Low Downgraded: risk of bias, imprecision |
Acute rejection Steroid avoidance vs steroid maintenance | RR 1.58 [1.08, 2.3] | 7 studies · 835 participants | Moderate Downgraded: risk of bias, imprecision |
NODAT Steroid avoidance vs steroid maintenance | RR 0.75 [0.51, 1.1] | 9 studies · 1618 participants | Low Downgraded: risk of bias, imprecision |
CMV Infection Steroid avoidance vs steroid maintenance | RR 0.96 [0.7, 1.31] | 6 studies · 1454 participants | Low Downgraded: imprecision |