Cochrane · systematic review · CD005625
Rutosides for treatment of post‐thrombotic syndrome
Morling, JR, Broderick, C, Yeoh, SE, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
6
No studies
6
Included studies
NR
No studies 6 · 50%Ungraded 0 · 0%Very low 0 · 0%Low 6 · 50%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyRutosides versus placebo (or no treatment) for the treatment of post‐thrombotic syndrome
Population: patients with PTS
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Occurrence of leg ulceration Rutosides vs placebo (or no treatment) | no estimate extracted | NR | No studies |
Improvement in PTS (8 weeks ‐ 12 months) Rutosides vs placebo (or no treatment) | OR 1.29 [0.69, 2.41] | 2 studies · 164 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Deterioration in PTS (8 weeks ‐ 12 months) Rutosides vs placebo (or no treatment) | OR 0.61 [0.19, 1.9] | 1 study · 80 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Adverse effects (8 weeks ‐ 12 months) Rutosides vs placebo (or no treatment) | no estimate extracted | NR | No studies |
Rutosides versus elastic compression stockings for the treatment of post‐thrombotic syndrome
Population: patients with PTS
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Occurrence of leg ulceration Rutosides vs elastic compression stockings | no estimate extracted | NR | No studies |
Improvement in PTS (12 months) Rutosides vs elastic compression stockings | OR 0.8 [0.31, 2.03] | 1 study · 80 participants | Low Downgraded: risk of bias, publication bias |
Deterioration in PTS (12 months) Rutosides vs elastic compression stockings | OR 0.61 [0.19, 1.9] | 1 study · 80 participants | Low Downgraded: risk of bias, publication bias |
Adverse effects (12 months) Rutosides vs elastic compression stockings | no estimate extracted | NR | No studies |
Rutosides versus an alternative venoactive remedy (hidrosmina) for the treatment of post‐thrombotic syndrome
Population: patients with PTS
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Occurrence of leg ulceration Rutosides vs an alternative venoactive remedy (hidrosmina) | no estimate extracted | NR | No studies |
Improvement in PTS (6 months) Rutosides vs an alternative venoactive remedy (hidrosmina) | OR 0.18 [0.04, 0.94] | 1 study · 29 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Deterioration in PTS (6 months) Rutosides vs an alternative venoactive remedy (hidrosmina) | OR 0.19 [0.01, 4.24] | 1 study · 29 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Adverse effects Rutosides vs an alternative venoactive remedy (hidrosmina) | no estimate extracted | NR | No studies |
Rutosides versus placebo or no comparator for the treatment of PTS
Population: People with post‐thrombotic syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement in PTS Rutosides vs placebo or no comparator | OR 1.29 [0.69, 2.41] | 2 studies · 164 participants | Very low Downgraded: risk of bias |
Deterioration in PTS Rutosides vs placebo or no comparator | OR 0.61 [0.19, 1.9] | 1 study · 80 participants | Very low Downgraded: risk of bias |
Rutosides versus elastic compression stockings for the treatment of PTS
Population: People with post‐thrombotic syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement in PTS Rutosides vs elastic compression stockings | OR 0.8 [0.31, 2.03] | 1 study · 80 participants | Low Downgraded: risk of bias |
Deterioration in PTS Rutosides vs elastic compression stockings | OR 0.61 [0.19, 1.9] | 1 study · 80 participants | Low Downgraded: risk of bias |
Rutosides versus hidrosmina for the treatment of PTS
Population: People with post‐thrombotic syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement in PTS Rutosides vs hidrosmina | OR 0.18 [0.04, 0.94] | 1 study · 29 participants | Low |
Deterioration in PTS Rutosides vs hidrosmina | OR 0.19 [0.01, 4.24] | 1 study · 29 participants | Low |