Cochrane · systematic review · CD005437
Pre‐admission antibiotics for suspected cases of meningococcal disease
Sudarsanam, TD, Rupali, P, Tharyan, P, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 14.3%Very low 1 · 14.3%Low 1 · 14.3%Moderate 4 · 57.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyCeftriaxone versus long‐acting (oily) chloramphenicol in people suspected to have meningococcal disease
Population: people suspected to have meningococcal disease (adults and children)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death ‐ in all participants ‐ short term Ceftriaxone vs long‐acting (oily) chloramphenicol | RR 1.21 [0.57, 2.56] | 1 study · 503 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Death ‐ in confirmed cases of meningococcal meningitis (subgroup) Ceftriaxone vs long‐acting (oily) chloramphenicol | RR 1.11 [0.35, 3.56] | 1 study · 308 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Clinical failure ‐ in all participants ‐ short term Composite clinical criteria10 Ceftriaxone vs long‐acting (oily) chloramphenicol | OR 0.83 [0.32, 2.15] | 1 study · 477 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Clinical failure ‐ in confirmed cases of meningococcal meningitis (subgroup) Composite clinical criteria10 Ceftriaxone vs long‐acting (oily) chloramphenicol | OR 1.39 [0.23, 8.47] | 1 study · 308 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Neurological sequelae ‐ in all participants‐ short term Clinical assessment11 Ceftriaxone vs long‐acting (oily) chloramphenicol | RR 1.29 [0.63, 2.62] | 1 study · 477 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Neurological sequelae ‐ in confirmed cases of meningococcal meningitis (subgroup) Clinical assesment11 Ceftriaxone vs long‐acting (oily) chloramphenicol | RR 1.44 [0.65, 3.23] | 1 study · 297 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Adverse events ‐ short term Ceftriaxone vs long‐acting (oily) chloramphenicol | no estimate extracted | 0 studies · 1 participants | Ungraded |
Cephalosporin versus long‐acting (oily) chloramphenicol compared in people suspected to have meningococcal disease
Population: people suspected to have meningococcal disease (adults and children)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death ‐ in all participants ‐ short‐term Cephalosporin vs long‐acting (oily) chloramphenicol compared | RR 1.21 [0.57, 2.56] | 1 study · 503 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Death ‐ in confirmed cases of meningococcal meningitis (subgroup) Cephalosporin vs long‐acting (oily) chloramphenicol compared | RR 1.11 [0.35, 3.56] | 1 study · 308 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Clinical failure ‐ in all participants ‐ short‐term Composite clinical criteria10 Cephalosporin vs long‐acting (oily) chloramphenicol compared | OR 0.83 [0.32, 2.15] | 1 study · 477 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Clinical failure ‐ in confirmed cases of meningococcal meningitis (subgroup) Composite clinical criteria10 Cephalosporin vs long‐acting (oily) chloramphenicol compared | OR 1.39 [0.23, 8.47] | 1 study · 308 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Neurological sequelae ‐ in all participants‐ short‐term Clinical assessment11 Cephalosporin vs long‐acting (oily) chloramphenicol compared | RR 1.29 [0.63, 2.62] | 1 study · 477 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Neurological sequelae ‐ in confirmed cases of meningococcal meningitis (subgroup) Clinical assesment11 Cephalosporin vs long‐acting (oily) chloramphenicol compared | RR 1.44 [0.65, 3.23] | 1 study · 297 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Adverse events‐ short‐term Cephalosporin vs long‐acting (oily) chloramphenicol compared | no estimate extracted | 0 studies · 1 participants | Ungraded |
Cephalosporin versus long‐acting (oily) Chloramphenicol compared in people suspected to have meningococcal disease
Population: people suspected to have meningococcal disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death ‐ in all participants‐ short term Cephalosporin vs long‐acting (oily) Chloramphenicol compared | RR 1.21 [0.57, 2.56] | 1 study · 503 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Death‐ in confirmed cases of meningococcal meningitis (subgroup) Cephalosporin vs long‐acting (oily) Chloramphenicol compared | RR 1.11 [0.35, 3.56] | 1 study · 308 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Clinical failure ‐ in all participants‐ short term Composite clinical criteria10 Cephalosporin vs long‐acting (oily) Chloramphenicol compared | OR 0.83 [0.32, 2.15] | 1 study · 477 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Clinical failure ‐ in confirmed cases of meningococcal meningitis (subgroup) Composite clinical criteria10 Cephalosporin vs long‐acting (oily) Chloramphenicol compared | OR 1.39 [0.23, 8.47] | 1 study · 308 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Neurological sequelae ‐ in all participants‐ short term Clinical assessment11 Cephalosporin vs long‐acting (oily) Chloramphenicol compared | RR 1.29 [0.63, 2.62] | 1 study · 477 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Neurological sequelae ‐ in confirmed cases of meningococcal meningitis (subgroup) Clinical assesment11 Cephalosporin vs long‐acting (oily) Chloramphenicol compared | RR 1.44 [0.65, 3.23] | 1 study · 297 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Adverse events‐ short term Cephalosporin vs long‐acting (oily) Chloramphenicol compared | no estimate extracted | 0 studies · 1 participants | Ungraded |