Cochrane · systematic review · CD005258
Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism
Kakkos, S, Kirkilesis, G, Caprini, JA, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 50%Low 3 · 37.5%Moderate 0 · 0%High 1 · 12.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyIPC plus pharmacological prophylaxis versus IPC alone
Population: people undergoing surgery or at risk of developing VTE due to surgery, trauma or ICU stay
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of PEa (early postoperative period) IPC plus pharmacological prophylaxis vs IPC alone | OR 0.51 [0.29, 0.91] | 19 studies · 5462 participants | Low Downgraded: risk of bias, imprecision |
Incidence of DVTc (early postoperative period) IPC plus pharmacological prophylaxis vs IPC alone | OR 0.51 [0.36, 0.72] | 18 studies · 5394 participants | Low Downgraded: risk of bias, imprecision |
Incidence of bleedingd (early postoperative period) IPC plus pharmacological prophylaxis vs IPC alone | OR 6.02 [3.88, 9.35] | 13 studies · 4634 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Incidence of major bleedingf (early postoperative period) IPC plus pharmacological prophylaxis vs IPC alone | OR 5.77 [2.81, 11.83] | 12 studies · 4133 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
IPC plus pharmacological prophylaxis versus pharmacological prophylaxis alone
Population: people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of PEa (early postoperative period) IPC plus pharmacological prophylaxis vs pharmacological prophylaxis alone | OR 0.46 [0.3, 0.71] | 15 studies · 6737 participants | Low Downgraded: risk of bias, imprecision |
Incidence of DVTc (early postoperative period) IPC plus pharmacological prophylaxis vs pharmacological prophylaxis alone | OR 0.38 [0.21, 0.7] | 17 studies · 6151 participants | High |
Incidence of bleedinge (early postoperative period) IPC plus pharmacological prophylaxis vs pharmacological prophylaxis alone | OR 0.87 | 6 studies · 1314 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Incidence of major bleedingg (early postoperative period) IPC plus pharmacological prophylaxis vs pharmacological prophylaxis alone | OR 1.21 [0.35, 4.18] | 5 studies · 908 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
IPC plus pharmacological prophylaxis versus IPC alone
Population: patients undergoing surgery or at risk of developing VTE because of other reasons (e.g. trauma)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of PEa IPC plus pharmacological prophylaxis vs IPC alone | OR 0.49 [0.18, 1.34] | 12 studies · 3017 participants | Moderate Downgraded: imprecision |
Incidence of DVTb IPC plus pharmacological prophylaxis vs IPC alone | OR 0.52 [0.33, 0.82] | 11 studies · 2934 participants | Moderate Downgraded: risk of bias |
Incidence of bleedingc IPC plus pharmacological prophylaxis vs IPC alone | OR 5.04 [2.36, 10.77] | 7 studies · 2155 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Incidence of major bleedingd IPC plus pharmacological prophylaxis vs IPC alone | OR 6.81 [1.99, 23.28] | 7 studies · 2155 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
IPC plus pharmacological prophylaxis versus pharmacological prophylaxis alone
Population: patients undergoing surgery or at risk of developing VTE because of other reasons (e.g. trauma)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of PEa IPC plus pharmacological prophylaxis vs pharmacological prophylaxis alone | OR 0.39 [0.23, 0.64] | 10 studies · 3544 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Incidence of DVTb IPC plus pharmacological prophylaxis vs pharmacological prophylaxis alone | OR 0.42 [0.18, 1.03] | 11 studies · 2866 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Incidence of bleedingc IPC plus pharmacological prophylaxis vs pharmacological prophylaxis alone | OR 0.8 | 3 studies · 244 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Incidence of major bleedingd IPC plus pharmacological prophylaxis vs pharmacological prophylaxis alone | OR 1.21 [0.35, 4.18] | 3 studies · 244 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |