Cochrane · systematic review · CD005143
Hyperbaric versus isobaric bupivacaine for spinal anaesthesia for caesarean section
Sng, BL, Siddiqui, FJ, Leong, WL, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 42.9%Low 2 · 28.6%Moderate 2 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyHyperbaric bupivacaine compared to Isobaric bupivacaine for spinal anaesthesia for caesarean section
Population: women with spinal anaesthesia for caesarean section
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Conversion to GA4 Hyperbaric bupivacaine vs Isobaric bupivacaine | RR 0.33 [0.09, 1.17] | 10 studies · 614 participants | Very low Downgraded: risk of bias |
Supplemental analgesia5 Hyperbaric bupivacaine vs Isobaric bupivacaine | RR 0.61 [0.26, 1.41] | 9 studies · 554 participants | Very low Downgraded: risk of bias |
Requirement for ephedrine6 Hyperbaric bupivacaine vs Isobaric bupivacaine | RR 0.89 [0.57, 1.38] | 4 studies · 256 participants | Very low Downgraded: risk of bias |
Nausea and vomiting7 Hyperbaric bupivacaine vs Isobaric bupivacaine | RR 0.99 [0.57, 1.72] | 7 studies · 433 participants | Low Downgraded: risk of bias |
Headache8 Participant‐reported Hyperbaric bupivacaine vs Isobaric bupivacaine | OR 1.82 [0.47, 6.99] | 3 studies · 234 participants | Low Downgraded: risk of bias |
Time to dermatomal block T4 block (mins) Hyperbaric bupivacaine vs Isobaric bupivacaine | no estimate extracted | 2 studies · 128 participants | Moderate Downgraded: risk of bias |
Amount of ephedrine used(mg/person) Hyperbaric bupivacaine vs Isobaric bupivacaine | no estimate extracted | 6 studies · 386 participants | Moderate Downgraded: risk of bias |
Comparison
Population: Pregnant women undergoing spinal anaesthesia for caesarean section
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Conversion to GA | no estimate extracted | 6 studies · 394 participants | Low Downgraded: imprecision |
Supplemental Analgesia | no estimate extracted | 6 studies · 394 participants | Low Downgraded: imprecision |
Requirement of ephedrine | no estimate extracted | 3 studies · 197 participants | Low Downgraded: imprecision |
Nausea and Vomiting | no estimate extracted | 5 studies · 335 participants | Moderate Downgraded: imprecision |
Headache | no estimate extracted | 3 studies · 234 participants | Low Downgraded: imprecision |
High block C8 | no estimate extracted | 3 studies · 206 participants | Moderate Downgraded: imprecision |