Cochrane · systematic review · CD005005

Hyperbaric oxygen therapy for late radiation tissue injury

Lin, ZC, Bennett, MH, Hawkins, GC, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library

Gynaecological, Neuro-oncology and Orphan Cancer3 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 57.1%Moderate 1 · 14.3%High 2 · 28.6%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Hyperbaric oxygen therapy (HBOT) compared to control without HBOT for late radiation tissue injury of any tissue

Population: any person with radiation tissue injury arising later than 6 months after irradiation (LRTI), including dysfunction or necrosis of any tissue

CD005005.PUB5 (current) · 4 questions

Outcome	Effect	Evidence	Status / GRADE
Death at 1 year Hyperbaric oxygen therapy (HBOT) vs control without HBOT	RR 0.93 [0.47, 1.83]	3 studies · 166 participants	Low Downgraded: risk of bias, imprecision
Complete or substantial improvement of condition Hyperbaric oxygen therapy (HBOT) vs control without HBOT	RR 1.39 [1.02, 1.89]	6 studies · 468 participants	Low Downgraded: risk of bias
Visual disturbances Hyperbaric oxygen therapy (HBOT) vs control without HBOT	RR 4.03 [1.65, 9.84]	5 studies · 438 participants	High
Otic barotrauma Hyperbaric oxygen therapy (HBOT) vs control without HBOT	RR 9.08 [2.21, 37.26]	4 studies · 357 participants	High

Hyperbaric oxygen therapy (HBOT) compared to control without HBOT for prevention or treatment of osteoradionecrosis of the mandible or maxilla

Population: any person with osteoradionecrosis of the jaw or at risk of osteoradionecrosis of the jaw

CD005005.PUB5 (current) · 3 questions

Outcome	Effect	Evidence	Status / GRADE
Wound dehiscence Hyperbaric oxygen therapy (HBOT) vs control without HBOT	RR 0.24 [0.06, 0.94]	2 studies · 264 participants	Low Downgraded: risk of bias, imprecision
Pain score change at 12 months Hyperbaric oxygen therapy (HBOT) vs control without HBOT	no estimate extracted	2 studies · 157 participants	Moderate Downgraded: imprecision
Complete resolution or significant improvement of osteoradionecrosis Hyperbaric oxygen therapy (HBOT) vs control without HBOT	RR 1.26 [0.87, 1.82]	3 studies · 239 participants	Low Downgraded: risk of bias, imprecision

Hyperbaric oxygen therapy versus standard approach for people with osteoradionecrosis

Population: late radiation tissue injury

CD005005.PUB4 · 2 questions

Outcome	Effect	Evidence	Status / GRADE
Complete mucosal cover in people with osteoradionecrosis (mucosal cover) Hyperbaric oxygen therapy vs standard approach	RR 1.3 [1.09, 1.55]	3 studies · 246 participants	Moderate Downgraded: risk of bias
Wound dehiscence following complex head and neck surgery (wound healing) Hyperbaric oxygen therapy vs standard approach	RR 4.23 [1.06, 16.83]	2 studies · 264 participants	Moderate Downgraded: risk of bias, imprecision

Hyperbaric oxygen therapy for late radiation tissue injury

Population: patients with late radiation tissue injury

CD005005.PUB3 · 1 question

Outcome	Effect	Evidence	Status / GRADE
Complete mucosal cover in patients with osteoradionecrosis Physical examination	RR 1.3 [1.1, 1.6]	3 studies · 246 participants	High