Cochrane · systematic review · CD004876
Vaccines for preventing influenza in the elderly
Demicheli, V, Jefferson, T, Di Pietrantonj, C, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Acute Respiratory InfectionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 2 · 28.6%Low 2 · 28.6%Moderate 2 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Influenza vaccine compared to placebo for preventing influenza in the elderly
Population: people aged over 65 years
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Influenza Influenza vaccine vs placebo | RR 0.42 [0.27, 0.66] | 3 studies · 2217 participants | Low Downgraded: risk of bias, indirectness |
Influenza‐like illness Influenza vaccine vs placebo | RR 0.59 [0.47, 0.73] | 4 studies · 6894 participants | Moderate Downgraded: risk of bias |
Pneumonia Influenza vaccine vs placebo | no estimate extracted | 1 study · 699 participants | Very low Downgraded: risk of bias, imprecision |
Hospitalisations ‐ not reported Influenza vaccine vs placebo | no estimate extracted | NR | No studies |
All deaths Influenza vaccine vs placebo | RR 1.02 [0.11, 9.72] | 1 study · 699 participants | Very low Downgraded: risk of bias, imprecision |
Fever Influenza vaccine vs placebo | RR 1.57 [0.92, 2.71] | 3 studies · 2519 participants | Moderate Downgraded: imprecision |
Nausea Influenza vaccine vs placebo | RR 1.75 [0.74, 4.12] | 1 study · 672 participants | Low Downgraded: risk of bias, imprecision |