Cochrane · systematic review · CD004786
Fluid therapy for acute bacterial meningitis
Maconochie, IK, Bhaumik, S · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
3
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 33.3%Low 2 · 66.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyMaintenance fluids versus restricted fluids for acute bacterial meningitis
Population: paediatric patients with acute bacterial meningitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death ‐ all participants Maintenance fluids vs restricted fluids | RR 0.82 [0.53, 1.27] | 2 studies · 407 participants | Low Downgraded: risk of bias |
Severe neurological sequelae ‐ acute (within the first 4 weeks) Maintenance fluids vs restricted fluids | RR 0.67 [0.41, 1.08] | 2 studies · 407 participants | Low Downgraded: risk of bias |
Severe neurological sequelae ‐ chronic (after the first 4 weeks) Maintenance fluids vs restricted fluids | RR 0.42 [0.2, 0.89] | 1 study · 351 participants | Very low Downgraded: risk of bias |
Maintenance fluids versus restricted fluids for acute bacterial meningitis in paediatric populations
Population: s
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death ‐ all patients Maintenance fluids vs restricted fluids | RR 0.82 [0.53, 1.27] | 2 studies · 407 participants | Moderate Downgraded: risk of bias, imprecision |
Severe neurological sequelae ‐ acute (within the first 4 weeks) Maintenance fluids vs restricted fluids | RR 0.67 [0.41, 1.08] | 2 studies · 407 participants | Very low Downgraded: risk of bias, imprecision |
Severe neurological sequelae ‐ chronic (after the first 4 weeks) Maintenance fluids vs restricted fluids | RR 0.42 [0.2, 0.89] | 1 study · 351 participants | Moderate Downgraded: risk of bias, imprecision |
Mild to moderate neurological sequelae Maintenance fluids vs restricted fluids | RR 1.24 [0.58, 2.65] | 1 study · 357 participants | Moderate Downgraded: risk of bias |