Cochrane · systematic review · CD004455
Antibiotic prophylaxis for operative vaginal delivery
Liabsuetrakul, T, Choobun, T, Peeyananjarassri, K, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
8
No studies
2
Included studies
NR
No studies 2 · 20%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 40%Moderate 1 · 10%High 3 · 30%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyAny antibiotics compared to placebo or no treatment for operative vaginal delivery
Population: operative vaginal delivery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fever ‐ not measured Any antibiotics vs placebo or no treatment | no estimate extracted | NR | No studies |
Infected episiotomy/laceration (superficial perineal wound infection) № of participants: 3420 (1 RCT) Any antibiotics vs placebo or no treatment | RR 0.53 [0.4, 0.69] | NR | High |
Infected episiotomy/laceration (deep perineal wound infection № of participants: 3420 (1 RCT) Any antibiotics vs placebo or no treatment | RR 0.46 [0.31, 0.69] | NR | High |
Infected episiotomy/laceration (organ or space infection) № of participants: 3420 (1 RCT) Any antibiotics vs placebo or no treatment | RR 0.11 [0.01, 2.05] | NR | Low Downgraded: imprecision |
Infected episiotomy/laceration (wound breakdown) № of participants: 2593 (1 RCT) Any antibiotics vs placebo or no treatment | RR 0.52 [0.43, 0.63] | NR | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Endometritis № of participants: 3813 (2 RCTs) Any antibiotics vs placebo or no treatment | RR 0.32 [0.04, 2.64] | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
Urinary tract infection ‐ not measured Any antibiotics vs placebo or no treatment | no estimate extracted | NR | No studies |
Serious infectious complications № of participants: 3420 (1 RCT) Any antibiotics vs placebo or no treatment | RR 0.44 [0.22, 0.89] | NR | High |
Maternal adverse reactions № of participants: 2593 (1 RCT) Any antibiotics vs placebo or no treatment | RR 2 [0.18, 22.05] | NR | Low Downgraded: imprecision |
Maternal length of stay № of participants: 393 (1 RCT) Any antibiotics vs placebo or no treatment | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
Any antibiotics versus placebo or no treatment for operative vaginal delivery
Population: women undergoing operative vaginal delivery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Endometritis Any antibiotics vs placebo or no treatment | RR 0.07 [0, 1.21] | 1 study · 393 participants | Low Downgraded: imprecision |
Maternal length of hospital stay (days) Any antibiotics vs placebo or no treatment | no estimate extracted | 1 study · 393 participants | Low Downgraded: imprecision |
Fever Any antibiotics vs placebo or no treatment | no estimate extracted | 0 participants | Ungraded |
Infected episiotomy/perineal/vaginal laceration Any antibiotics vs placebo or no treatment | no estimate extracted | 0 participants | Ungraded |
Urinary tract infection Any antibiotics vs placebo or no treatment | no estimate extracted | 0 participants | Ungraded |
Serious infectious complications Any antibiotics vs placebo or no treatment | no estimate extracted | 0 participants | Ungraded |
Maternal adverse reactions Any antibiotics vs placebo or no treatment | no estimate extracted | 0 participants | Ungraded |
Any antibiotics versus placebo or no treatment for operative vaginal delivery
Population: Women undergoing operative vaginal delivery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Endometritis Any antibiotics vs placebo or no treatment | RR 0.07 [0, 1.21] | 1 study · 393 participants | Low Downgraded: imprecision |
Maternal length of stay Any antibiotics vs placebo or no treatment | no estimate extracted | 1 study · 393 participants | Low Downgraded: imprecision |
Fever Any antibiotics vs placebo or no treatment | no estimate extracted | 0 participants | Ungraded |
Infected episiotomy/perineal/vaginal laceration Any antibiotics vs placebo or no treatment | no estimate extracted | 0 participants | Ungraded |
Urinary tract infection Any antibiotics vs placebo or no treatment | no estimate extracted | 0 participants | Ungraded |
Serious infectious complications Any antibiotics vs placebo or no treatment | no estimate extracted | 0 participants | Ungraded |
Maternal adverse reactions Any antibiotics vs placebo or no treatment | no estimate extracted | 0 participants | Ungraded |