Cochrane · systematic review · CD004198
Treatments for priapism in boys and men with sickle cell disease
Chinegwundoh, FI, Smith, S, Anie, KA · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
26
current version
GRADE rated
9
No studies
17
Included studies
NR
No studies 17 · 65.4%Ungraded 0 · 0%Very low 7 · 26.9%Low 2 · 7.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlySilboesterol versus placebo
Population: men and boys with SCD and stuttering priapism
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Detumescence Silboesterol vs placebo | no estimate extracted | NR | No studies |
Reduction in stuttering priapism Silboesterol vs placebo | RR 2.92 [0.73, 11.7] | 1 study · 7 participants | Very low Downgraded: risk of bias, imprecision |
Immediate side effects of treatment Silboesterol vs placebo | no estimate extracted | NR | No studies |
Effect on later sexual function Silboesterol vs placebo | no estimate extracted | NR | No studies |
Other untoward side effects of treatment Silboesterol vs placebo | no estimate extracted | NR | No studies |
Efficacy of a prevention strategy Silboesterol vs placebo | no estimate extracted | NR | No studies |
Sildenafil versus placebo
Population: men and boys with SCD and stuttering priapism
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Detumescence Sildenafil vs placebo | no estimate extracted | NR | No studies |
Reduction in frequency of priapism Sildenafil vs placebo | RR 0.58 [0.07, 4.95] | 1 study · 13 participants | Low Downgraded: risk of bias, imprecision |
Immediate side effects of treatment Sildenafil vs placebo | no estimate extracted | 1 study · 13 participants | Low Downgraded: risk of bias, indirectness |
Effect on later sexual function Sildenafil vs placebo | no estimate extracted | NR | No studies |
Other untoward side effects of treatment Sildenafil vs placebo | no estimate extracted | NR | No studies |
Efficacy of a prevention strategy Sildenafil vs placebo | no estimate extracted | NR | No studies |
Etilefrine versus placebo
Population: men and boys with SCD and stuttering priapism
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Detumescence Etilefrine vs placebo | no estimate extracted | NR | No studies |
Reduction in frequency of priapism Etilefrine vs placebo | no estimate extracted | 1 study · 23 participants | Very low Downgraded: risk of bias, imprecision |
Immediate side effects of treatment (palpitations) Etilefrine vs placebo | RR 1.64 [0.62, 4.3] | 1 study · 23 participants | Very low Downgraded: risk of bias, imprecision |
Immediate side effects of treatment (tachycardia) Etilefrine vs placebo | RR 2.18 [0.71, 6.68] | 1 study · 23 participants | Very low Downgraded: risk of bias, imprecision |
Effect on later sexual function Etilefrine vs placebo | no estimate extracted | NR | No studies |
Other untoward side effects of treatment Etilefrine vs placebo | no estimate extracted | NR | No studies |
Efficacy of a prevention strategy Etilefrine vs placebo | no estimate extracted | NR | No studies |
Ephedrine versus placebo
Population: men and boys with SCD and stuttering priapism
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Detumescence Ephedrine vs placebo | no estimate extracted | NR | No studies |
Reduction in frequency of priapism Ephedrine vs placebo | no estimate extracted | 1 study · 24 participants | Very low Downgraded: risk of bias, imprecision |
Immediate side effects of treatment with 30 mg ephedrine (palpitations) Ephedrine vs placebo | RR 1 [0.32, 3.1] | 1 study · 24 participants | Very low Downgraded: risk of bias, imprecision |
Immediate side effects of treatment with 30 mg ephedrine (tachycardia) Ephedrine vs placebo | RR 0.67 [0.13, 3.3] | 1 study · 24 participants | Very low Downgraded: risk of bias, imprecision |
Effect on later sexual function Ephedrine vs placebo | no estimate extracted | NR | No studies |
Other untoward side effects of treatment Ephedrine vs placebo | no estimate extracted | NR | No studies |
Efficacy of a prevention strategy Ephedrine vs placebo | no estimate extracted | NR | No studies |
Silboesterol versus placebo
Population: men and boys with SCD and stuttering priapism
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Detumescence Silboesterol vs placebo | no estimate extracted | NR | No studies |
Reduction in stuttering priapism Silboesterol vs placebo | RR 2.92 [0.73, 11.7] | 1 study · 7 participants | Very low Downgraded: risk of bias, imprecision |
Immediate side effects of treatment Silboesterol vs placebo | no estimate extracted | NR | No studies |
Effect on later sexual function Silboesterol vs placebo | no estimate extracted | NR | No studies |
Other untoward side effects of treatment Silboesterol vs placebo | no estimate extracted | NR | No studies |
Efficacy of a prevention strategy Silboesterol vs placebo | no estimate extracted | NR | No studies |
Sildenafil versus placebo
Population: men and boys with SCD and stuttering priapism
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Detumescence Sildenafil vs placebo | no estimate extracted | NR | No studies |
Reduction in frequency of priapism Sildenafil vs placebo | RR 0.58 [0.07, 4.95] | 1 study · 13 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Immediate side effects of treatment Sildenafil vs placebo | no estimate extracted | 1 study · 13 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Effect on later sexual function Sildenafil vs placebo | no estimate extracted | NR | No studies |
Other untoward side effects of treatment Sildenafil vs placebo | no estimate extracted | NR | No studies |
Efficacy of a prevention strategy Sildenafil vs placebo | no estimate extracted | NR | No studies |
Etilefrine versus placebo
Population: men and boys with SCD and stuttering priapism
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Detumescence Etilefrine vs placebo | no estimate extracted | NR | No studies |
Reduction in frequency of priapism Etilefrine vs placebo | no estimate extracted | 1 study · 23 participants | Very low Downgraded: risk of bias, imprecision |
Immediate side effects of treatment (palpitations) Etilefrine vs placebo | RR 1.64 [0.62, 4.3] | 1 study · 23 participants | Very low Downgraded: risk of bias, imprecision |
Immediate side effects of treatment (tachycardia) Etilefrine vs placebo | RR 2.18 [0.71, 6.68] | 1 study · 23 participants | Very low Downgraded: risk of bias, imprecision |
Effect on later sexual function Etilefrine vs placebo | no estimate extracted | NR | No studies |
Other untoward side effects of treatment Etilefrine vs placebo | no estimate extracted | NR | No studies |
Efficacy of a prevention strategy Etilefrine vs placebo | no estimate extracted | NR | No studies |
Ephedrine versus placebo
Population: men and boys with SCD and stuttering priapism
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Detumescence Ephedrine vs placebo | no estimate extracted | NR | No studies |
Reduction in frequency of priapism Ephedrine vs placebo | no estimate extracted | 1 study · 24 participants | Very low Downgraded: risk of bias, imprecision |
Immediate side effects of treatment with 30 mg ephedrine (palpitations) Ephedrine vs placebo | RR 1 [0.32, 3.1] | 1 study · 24 participants | Very low Downgraded: risk of bias, imprecision |
Immediate side effects of treatment with 30 mg ephedrine (tachycardia) Ephedrine vs placebo | RR 0.67 [0.13, 3.3] | 1 study · 24 participants | Very low Downgraded: risk of bias, imprecision |
Effect on later sexual function Ephedrine vs placebo | no estimate extracted | NR | No studies |
Other untoward side effects of treatment Ephedrine vs placebo | no estimate extracted | NR | No studies |
Efficacy of a prevention strategy Ephedrine vs placebo | no estimate extracted | NR | No studies |