Cochrane · systematic review · CD004106
Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in adults and children
Lasserson, TJ, Ferrara, G, Casali, L · Cochrane Database of Systematic Reviews · 2011 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 20%Moderate 4 · 80%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyCombination fluticasone/salmeterol versus budesonide/formoterol for chronic asthma in adults and children
Population: Patients with chronic asthma in adults and children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participants experiencing exacerbations requiring oral steroid treatment Combination fluticasone/salmeterol vs budesonide/formoterol | OR 0.89 [0.74, 1.07] | 4 studies · 4949 participants | Moderate Downgraded: imprecision |
Participants experiencing exacerbations requiring admission to hospital Combination fluticasone/salmeterol vs budesonide/formoterol | OR 1.29 [0.68, 2.47] | 4 studies · 4879 participants | Moderate Downgraded: imprecision |
Asthma‐related serious adverse event Combination fluticasone/salmeterol vs budesonide/formoterol | OR 1.47 [0.75, 2.86] | 3 studies · 4054 participants | Moderate Downgraded: imprecision |
Mortality Combination fluticasone/salmeterol vs budesonide/formoterol | no estimate extracted | 5 studies · 4819 participants | Low Downgraded: imprecision |
Withdrawals (adverse events) Combination fluticasone/salmeterol vs budesonide/formoterol | OR 0.94 [0.6, 1.46] | 5 studies · 5082 participants | Moderate Downgraded: imprecision |
Combination fluticasone/salmeterol or budesonide/formoterol for chronic asthma in adults
Population: patients with chronic asthma in adults1
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participants experiencing exacerbations requiring oral steroid treatment | OR 0.89 [0.74, 1.07] | 4 studies · 4949 participants | Moderate Downgraded: imprecision |
Participants experiencing exacerbations requiring admission to hospital | OR 1.29 [0.68, 2.47] | 4 studies · 4879 participants | Moderate Downgraded: imprecision |
Asthma‐related serious adverse event | OR 1.47 [0.75, 2.86] | 3 studies · 4054 participants | Moderate Downgraded: imprecision |