Cochrane · systematic review · CD003840
Eradication therapy for peptic ulcer disease in Helicobacter pylori‐positive people
Ford, AC, Gurusamy, KS, Delaney, B, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 50%Low 2 · 50%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyAdditional Helicobacter pylori eradication therapy for acute ulcer healing in people with Helicobacter pylori‐positive peptic ulcer
Population: people with Helicobacter pylori‐positive peptic ulcer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
H. pylori eradication therapy plus ulcer healing drug versus ulcer healing drug alone | RR 0.66 [0.58, 0.76] | 34 studies · 3910 participants | Low Downgraded: risk of bias, publication bias |
H. pylori eradication therapy versus no active treatment | RR 0.37 [0.26, 0.53] | 2 studies · 207 participants | Low Downgraded: risk of bias, imprecision |
Additional Helicobacter pylori eradication therapy for prevention of recurrence in people with Helicobacter‐positive peptic ulcer
Population: prevention of recurrence in people with Helicobacter pylori‐positive peptic ulcer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
H. pylori eradication therapy versus ulcer healing drug alone | RR 0.73 [0.42, 1.25] | 4 studies · 319 participants | Very low Downgraded: risk of bias, imprecision |
H. pylori eradication therapy versus no active treatment | RR 0.2 [0.15, 0.26] | 27 studies · 2509 participants | Very low Downgraded: risk of bias, inconsistency, publication bias |
duodenal ulcer acute healing with H. pylori eradication + ulcer healing drug compared to ulcer healing drug alone for peptic ulcer disease in Helicobacter pylori positive patients
Population: patients with peptic ulcer disease in Helicobacter pylori positive patients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion not healed duodenal ulcer acute healing with H. pylori eradication + ulcer healing drug vs ulcer healing drug alone | RR 0.66 [0.58, 0.76] | 34 studies · 3910 participants | Ungraded |
duodenal ulcer acute healing with H. pylori eradication compared to no treatment / placebo for peptic ulcer disease in Helicobacter pylori positive patients
Population: patients with peptic ulcer disease in Helicobacter pylori positive patients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion not healed duodenal ulcer acute healing with H. pylori eradication vs no treatment / placebo | RR 0.37 [0.26, 0.53] | 2 studies · 207 participants | Ungraded |
gastric ulcer acute healing with H. pylori eradication + ulcer healing drug compared to ulcer healing drug alone for peptic ulcer disease in Helicobacter pylori positive patients
Population: patients with peptic ulcer disease in Helicobacter pylori positive patients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion not healed gastric ulcer acute healing with H. pylori eradication + ulcer healing drug vs ulcer healing drug alone | RR 1.23 [0.9, 1.68] | 15 studies · 1974 participants | Ungraded |
duodenal ulcer recurrence with H. pylori eradication compared to no treatment (after initial ulcer healing) for peptic ulcer disease in Helicobacter pylori positive patients
Population: patients with peptic ulcer disease in Helicobacter pylori positive patients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion recurred duodenal ulcer recurrence with H. pylori eradication vs no treatment (after initial ulcer healing) | RR 0.2 [0.15, 0.26] | 27 studies · 2509 participants | Ungraded |
gastric ulcer recurrence with H. pylori eradication compared to no treatment (after initial ulcer healing) for peptic ulcer disease in Helicobacter pylori positive patients
Population: patients with peptic ulcer disease in Helicobacter pylori positive patients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion recurred gastric ulcer recurrence with H. pylori eradication vs no treatment (after initial ulcer healing) | RR 0.31 [0.22, 0.45] | 12 studies · 1476 participants | Ungraded |