Cochrane · systematic review · CD003648
Vitamin A supplements for reducing mother‐to‐child HIV transmission
Wiysonge, CS, Ndze, VN, Kongnyuy, EJ, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 42.9%Low 2 · 28.6%Moderate 2 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyEffects of giving vitamin A supplements to HIV‐positive women during pregnancy or after delivery
Population: HIV‐positive women during pregnancy and immediate postpartum period
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
HIV infection status of the child | RR 1.07 [0.91, 1.26] | 5 studies · 4428 participants | Moderate Downgraded: imprecision |
Mean birthweight | MD 34.12 | 3 studies · 2181 participants | Low Downgraded: imprecision |
Low birthweight | RR 0.78 [0.63, 0.97] | 3 studies · 1819 participants | Moderate Downgraded: imprecision |
Child death by two years of age | RR 1.06 [0.92, 1.22] | 3 studies · 3883 participants | Low Downgraded: imprecision |
Preterm delivery | RR 0.84 [0.52, 1.37] | 2 studies · 1577 participants | Very low Downgraded: risk of bias, imprecision |
Stillbirth | RR 1.13 [0.72, 1.77] | 3 studies · 2335 participants | Very low Downgraded: risk of bias, imprecision |
Maternal death | RR 0.71 [0.35, 1.43] | 2 studies · 1267 participants | Very low Downgraded: risk of bias, imprecision |
The effects of vitamin A supplementation of HIV infected women
Population: HIV infected women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
HIV infection in child | RR 1.04 [0.87, 1.24] | 4 studies · 6517 participants | Moderate Downgraded: inconsistency |
Still birth | RR 0.99 [0.68, 1.43] | 4 studies · 2855 participants | Moderate Downgraded: imprecision |
Preterm births | RR 0.88 [0.65, 1.19] | 3 studies · 2110 participants | Moderate Downgraded: imprecision |
Low birth weight | RR 0.83 [0.68, 1.01] | 4 studies · 2606 participants | Moderate Downgraded: imprecision |
Birth weight | no estimate extracted | 3 studies · 1809 participants | High |
Maternal death | RR 0.49 [0.04, 5.37] | 1 study · 728 participants | Very low Downgraded: imprecision |
Child death by 24 months | RR 1.03 [0.88, 1.2] | 2 studies · 1635 participants | Moderate Downgraded: imprecision |