Cochrane · systematic review · CD003343
Directly observed therapy for treating tuberculosis
Karumbi, J, Garner, P · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 5 · 71.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Directly observed therapy (DOT) versus self‐administered TB treatment
Population: Patients on TB treatment
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cure Directly observed therapy (DOT) vs self‐administered TB treatment | RR 1.08 [0.91, 1.27] | 5 studies · 1645 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Treatment completion Directly observed therapy (DOT) vs self‐administered TB treatment | RR 1.07 [0.96, 1.19] | 6 studies · 1839 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Home DOT versus clinic DOT
Population: Patients with TB treatment
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cure Home DOT vs clinic DOT | RR 1.02 [0.88, 1.18] | 4 studies · 1556 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Treatment completion4 Home DOT vs clinic DOT | RR 1.04 [0.91, 1.17] | 3 studies · 1029 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Summary of findings table 3
Population: Patients on TB treatment
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cure | RR 1.02 [0.86, 1.21] | 2 studies · 1493 participants | Moderate Downgraded: risk of bias |
Treatment completion | RR 1.05 [0.9, 1.22] | 2 studies · 1493 participants | Low Downgraded: risk of bias |
DOT versus self‐administered therapy for intravenous drug users
Population: Patients on TB treatment
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment completion DOT vs self‐administered therapy | RR 1 [0.88, 1.13] | 1 study · 300 participants | Low Downgraded: risk of bias, imprecision, indirectness |