Cochrane · systematic review · CD003264
Growth hormone for children with chronic kidney disease
Hodson, EM, Willis, NS, Craig, JC · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 50%Moderate 4 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
rhGH 28 IU/m²/wk versus placebo/no treatment for children with chronic kidney disease
Population: children with chronic kidney disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
HSDS after 1 year of rhGH rhGH 28 IU/m²/wk vs placebo/no treatment | no estimate extracted | 8 studies · 331 participants | Moderate Downgraded: risk of bias |
Height velocity (cm/6 mo) after 6 months of rhGH from baseline to 6 months rhGH 28 IU/m²/wk vs placebo/no treatment | no estimate extracted | 2 studies · 27 participants | Low Downgraded: risk of bias |
Height velocity (cm/y) after 1 year of rhGH rhGH 28 IU/m²/wk vs placebo/no treatment | no estimate extracted | 7 studies · 287 participants | Moderate Downgraded: risk of bias |
Change in height velocity SDS from baseline to 6 months rhGH 28 IU/m²/wk vs placebo/no treatment | no estimate extracted | 2 studies · 27 participants | Low Downgraded: risk of bias |
Change in height velocity SDS from baseline to 1 year rhGH 28 IU/m²/wk vs placebo/no treatment | no estimate extracted | 2 studies · 22 participants | Low Downgraded: risk of bias |
rhGH 28 IU/m²/wk versus 14 IU/m²/wk for children with chronic kidney disease
Population: children with chronic kidney disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Final or change in HSDS from baseline to 1 year rhGH 28 IU/m²/wk vs 14 IU/m²/wk | no estimate extracted | 3 studies · 145 participants | Moderate Downgraded: risk of bias, imprecision |
Change in height velocity (cm/time period) from baseline to 1 year rhGH 28 IU/m²/wk vs 14 IU/m²/wk | no estimate extracted | 3 studies · 150 participants | Moderate Downgraded: risk of bias, imprecision |
Change in height velocity SDS from baseline to 1 year rhGH 28 IU/m²/wk vs 14 IU/m²/wk | no estimate extracted | 2 studies · 106 participants | Low Downgraded: risk of bias, imprecision |