Cochrane · systematic review · CD003149
Preoperative blood transfusions for sickle cell disease
Estcourt, LJ, Kimber, C, Trivella, M, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
9
No studies
1
Included studies
NR
No studies 1 · 7.1%Ungraded 4 · 28.6%Very low 8 · 57.1%Low 1 · 7.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyAggressive versus conservative blood transfusion for sickle cell disease (SCD)
Population: people with SCD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Aggressive vs conservative blood transfusion | no estimate extracted | 1 study · 230 participants | Ungraded |
Serious complications related to SCD ‐ cholecystectomy ACS Aggressive vs conservative blood transfusion | RR 0.84 [0.38, 1.84] | 1 study · 230 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Serious complications related to SCD ‐ cholecystectomy painful crisis Aggressive vs conservative blood transfusion | RR 0.3 [0.09, 1.04] | 1 study · 230 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Serious infection ‐ cholecystectomy Aggressive vs conservative blood transfusion | RR 1.75 [0.59, 5.18] | 1 study · 230 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Perioperative complications ‐ cholecystectomy complications (any) Aggressive vs conservative blood transfusion | RR 0.75 [0.36, 1.55] | 1 study · 230 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Transfusion‐related complications ‐ cholecystectomy complications (any) Aggressive vs conservative blood transfusion | RR 1.85 [0.89, 3.88] | 1 study · 230 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Quality of life Aggressive vs conservative blood transfusion | no estimate extracted | NR | No studies |
Preoperative blood transfusion versus no transfusion for sickle cell disease (SCD)
Population: people with SCD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Preoperative blood transfusion vs no transfusion | no estimate extracted | 2 studies · 434 participants | Ungraded |
Serious complications related to SCD ‐ ACS Preoperative blood transfusion vs no transfusion | no estimate extracted | 2 studies · 434 participants | Very low Downgraded: risk of bias, imprecision |
Serious complications related to SCD ‐ painful crises Preoperative blood transfusion vs no transfusion | OR 1.91 [0.61, 6.04] | 2 studies · 434 participants | Very low Downgraded: risk of bias, imprecision |
Serious infection Preoperative blood transfusion vs no transfusion | OR 1.29 [0.29, 5.71] | 2 studies · 434 participants | Very low Downgraded: risk of bias, imprecision |
Perioperative complications ‐ any surgery‐related Preoperative blood transfusion vs no transfusion | RR 0.24 [0.03, 2.05] | 1 study · 65 participants | Low Downgraded: risk of bias, imprecision |
Transfusion related complications ‐ any Preoperative blood transfusion vs no transfusion | no estimate extracted | 2 studies · 434 participants | Ungraded |
Quality of life Preoperative blood transfusion vs no transfusion | no estimate extracted | 1 study · 19 participants | Ungraded |
Aggressive versus conservative blood transfusion for sickle cell disease (SCD)
Population: people with SCD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Aggressive vs conservative blood transfusion | no estimate extracted | 1 study · 230 participants | Ungraded |
Serious complications related to SCD ‐ cholecystectomy ACS Aggressive vs conservative blood transfusion | RR 0.84 [0.38, 1.84] | 1 study · 230 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Serious complications related to SCD ‐ cholecystectomy painful crisis Aggressive vs conservative blood transfusion | RR 0.3 [0.09, 1.04] | 1 study · 230 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Serious infection ‐ cholecystectomy Aggressive vs conservative blood transfusion | RR 1.75 [0.59, 5.18] | 1 study · 230 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Perioperative complications ‐ cholecystectomy complications (any) Aggressive vs conservative blood transfusion | RR 0.75 [0.36, 1.55] | 1 study · 230 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Transfusion‐related complications ‐ cholecystectomy complications (any) Aggressive vs conservative blood transfusion | RR 1.85 [0.89, 3.88] | 1 study · 230 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Quality of life Aggressive vs conservative blood transfusion | no estimate extracted | NR | No studies |
Preoperative blood transfusion versus no transfusion for sickle cell disease (SCD)
Population: people with SCD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Preoperative blood transfusion vs no transfusion | no estimate extracted | 2 studies · 434 participants | Ungraded |
Serious complications related to SCD ‐ ACS Preoperative blood transfusion vs no transfusion | no estimate extracted | 2 studies · 434 participants | Very low Downgraded: risk of bias, imprecision |
Serious complications related to SCD ‐ painful crises Preoperative blood transfusion vs no transfusion | OR 1.91 [0.61, 6.04] | 2 studies · 434 participants | Very low Downgraded: risk of bias, imprecision |
Serious infection Preoperative blood transfusion vs no transfusion | OR 1.29 [0.29, 5.71] | 2 studies · 434 participants | Very low Downgraded: risk of bias, imprecision |
Perioperative complications ‐ any surgery‐related Preoperative blood transfusion vs no transfusion | RR 0.24 [0.03, 2.05] | 1 study · 65 participants | Low Downgraded: risk of bias, imprecision |
Transfusion related complications ‐ any Preoperative blood transfusion vs no transfusion | no estimate extracted | 2 studies · 434 participants | Ungraded |
Quality of life Preoperative blood transfusion vs no transfusion | no estimate extracted | 1 study · 19 participants | Ungraded |