Cochrane · systematic review · CD002898
Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis
Wilhelmus, KR · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
28
current version
GRADE rated
24
No studies
4
Included studies
NR
No studies 4 · 14.3%Ungraded 0 · 0%Very low 1 · 3.6%Low 7 · 25%Moderate 16 · 57.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyRelative healing outcomes with topical antiviral therapy
Population: trial participants with dendritic or geographic epithelial keratitis Outcomes: corneal epithelial healing at 7 and 14 days
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment comparisons | no estimate extracted | NR | No studies |
Idoxuridine (B) versus inactive control (A) | no estimate extracted | 7 participants | Low Downgraded: risk of bias, inconsistency |
Vidarabine (B) versus inactive control (A) | no estimate extracted | 7 participants | Low |
Vidarabine (B) versus idoxuridine (A) | no estimate extracted | 7 participants | Moderate |
Trifluridine (B) versus idoxuridine (A) | no estimate extracted | 7 participants | Moderate Downgraded: risk of bias, inconsistency |
Acyclovir (B) versus idoxuridine (A) | no estimate extracted | 7 participants | Moderate Downgraded: risk of bias, inconsistency |
Brivudine (B) versus idoxuridine (A) | no estimate extracted | 7 participants | Moderate |
Trifluridine (B) versus vidarabine (A) | no estimate extracted | 7 participants | Moderate Downgraded: risk of bias, inconsistency |
Acyclovir (B) versus vidarabine (A) | no estimate extracted | 7 participants | Moderate Downgraded: inconsistency |
Acyclovir (B) versus trifluridine (A) | no estimate extracted | 7 participants | Moderate Downgraded: risk of bias, inconsistency, indirectness, publication bias |
Brivudine (B) versus trifluridine (A) | no estimate extracted | 7 participants | Moderate Downgraded: risk of bias, inconsistency |
Brivudine (B) versus acyclovir (A) | no estimate extracted | 7 participants | Moderate |
Ganciclovir (B) versus acyclovir (A) | no estimate extracted | 7 participants | Low Downgraded: risk of bias, inconsistency, publication bias |
Foscarnet (B) versus trifluridine (A) | no estimate extracted | 7 participants | Moderate |
Foscarnet (B) versus acyclovir (A) | no estimate extracted | 7 participants | Moderate |
Foscarnet (B) versus ganciclovir (A) | no estimate extracted | 7 participants | Moderate |
Relative healing outcomes with combined topical or topical and oral antiviral therapy
Population: trial participants with dendritic or geographic epithelial keratitis Outcomes: corneal epithelial healing at 7 and 14 days
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment comparisons | no estimate extracted | NR | No studies |
Topical acyclovir/vidarabine (B) versus topical acyclovir (A) | no estimate extracted | 7 participants | Moderate Downgraded: inconsistency |
Oral antiviral (B) versus topical antiviral (A) | no estimate extracted | 7 participants | Low Downgraded: inconsistency |
Oral antiviral + topical antiviral (B) versus topical antiviral (A) | no estimate extracted | 7 participants | Low Downgraded: inconsistency |
Relative healing outcomes with topical interferon
Population: trial participants with dendritic or geographic epithelial keratitis Outcomes: corneal epithelial healing at 7 and 14 days
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment comparisons | no estimate extracted | NR | No studies |
Interferon (B) versus inactive control (A) | no estimate extracted | 7 participants | Very low Downgraded: inconsistency |
Interferon (B) versus antiviral (A) | no estimate extracted | 7 participants | Low Downgraded: inconsistency |
Interferon + antiviral (B) versus antiviral (A) | no estimate extracted | 7 participants | Moderate |
Relative healing outcomes with corneal debridement
Population: trial participants with dendritic or geographic epithelial keratitis Outcomes: corneal epithelial healing at 7 and 14 days
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment comparisons | no estimate extracted | NR | No studies |
Antiviral (B) versus debridement (A) | no estimate extracted | 7 participants | Low Downgraded: inconsistency |
Debridement + antiviral or interferon (B) versus debridement (A) | no estimate extracted | 7 participants | Moderate Downgraded: inconsistency |
Debridement + antiviral (B) versus antiviral (A) | no estimate extracted | 7 participants | Moderate Downgraded: inconsistency |
Summary of findings: relative healing outcome with topical antiviral therapy
Population: trial participants with dendritic or geographic epithelial keratitis Outcomes: corneal epithelial healing after 7 days and after 14 days
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment comparisons | no estimate extracted | NR | No studies |
Idoxuridine (B) vs. inactive control (A) | no estimate extracted | 7 participants | Moderate Downgraded: risk of bias |
Vidarabine (B) vs. idoxuridine (A) | no estimate extracted | 7 participants | Moderate Downgraded: risk of bias, inconsistency, indirectness, publication bias |
Trifluridine (B) vs. idoxuridine (A) | no estimate extracted | 7 participants | Moderate Downgraded: risk of bias |
Acyclovir (B) vs. idoxuridine (A) | no estimate extracted | 7 participants | Moderate Downgraded: risk of bias |
Brivudine (B) vs. idoxuridine (A) | no estimate extracted | 7 participants | Moderate Downgraded: risk of bias, inconsistency, indirectness, publication bias |
Trifluridine (B) vs. vidarabine (A) | no estimate extracted | 7 participants | Moderate Downgraded: risk of bias |
Acyclovir (B) vs. vidarabine (A) | no estimate extracted | 7 participants | Moderate Downgraded: risk of bias, inconsistency, indirectness, publication bias |
Acyclovir (B) vs. trifluridine (A) | no estimate extracted | 7 participants | High |
Brivudine (B) vs. trifluridine (A) | no estimate extracted | 7 participants | Moderate Downgraded: risk of bias |
Brivudine (B) vs. acyclovir (A) | no estimate extracted | 7 participants | Moderate Downgraded: risk of bias, inconsistency, indirectness, publication bias |
Ganciclovir (B) vs. acyclovir (A) | no estimate extracted | 7 participants | Moderate Downgraded: risk of bias |
Summary of findings: relative healing outcome with oral antiviral therapy
Population: trial participants with dendritic or geographic epithelial keratitis Outcomes: corneal epithelial healing after 7 days and after 14 days
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment comparisons | no estimate extracted | NR | No studies |
Oral antiviral (B) vs. topical antiviral (A) | no estimate extracted | 7 participants | Low Downgraded: inconsistency |
Oral antiviral + topical antiviral (B) vs. topical antiviral (A) | no estimate extracted | 7 participants | Low Downgraded: inconsistency |
Summary of findings: relative healing outcome with topical interferon
Population: trial participants with dendritic or geographic epithelial keratitis Outcomes: corneal epithelial healing after 7 days and after 14 days
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment comparisons | no estimate extracted | NR | No studies |
Interferon (B) vs. inactive control (A) | no estimate extracted | 7 participants | Low Downgraded: inconsistency |
Interferon (B) vs. antiviral (A) | no estimate extracted | 7 participants | Low Downgraded: inconsistency |
Interferon + antiviral (B) vs. antiviral (A) | no estimate extracted | 7 participants | High |
Summary of findings: relative healing outcome with débridement methods
Population: trial participants with dendritic or geographic epithelial keratitis Outcomes: corneal epithelial healing after 7 days and after 14 days
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment comparisons | no estimate extracted | NR | No studies |
Antiviral (B) vs. débridement (A) | no estimate extracted | 7 participants | Low Downgraded: inconsistency |
Débridement + antiviral or interferon (B) vs. débridement (A) | no estimate extracted | 7 participants | Moderate Downgraded: inconsistency |
Débridement + antiviral (B) vs. antiviral (A) | no estimate extracted | 7 participants | Moderate Downgraded: inconsistency |