Cochrane · systematic review · CD002896
Vagus nerve stimulation for focal seizures
Panebianco, M, Rigby, A, Marson, AG · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 5 · 71.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyHigh versus low stimulation for focal seizures
Population: people with focal seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
50% reduction in seizure frequency (responders) High vs low stimulation | RR 1.73 [1.13, 2.64] | 4 studies · 373 participants | Moderate Downgraded: risk of bias, imprecision |
Withdrawals High vs low stimulation | RR 2.56 [0.51, 12.71] | 4 studies · 375 participants | Low Downgraded: risk of bias, imprecision |
Voice alteration or hoarseness High vs low stimulation | RR 2.17 [1.49, 3.17] | 3 studies · 330 participants | Moderate Downgraded: risk of bias, imprecision |
Cough High vs low stimulation | RR 1.09 [0.74, 1.62] | 3 studies · 334 participants | Moderate Downgraded: risk of bias, imprecision |
Dyspnoea High vs low stimulation | RR 2.45 [1.07, 5.6] | 2 studies · 312 participants | Low Downgraded: risk of bias, imprecision |
Pain High vs low stimulation | RR 1.01 [0.6, 1.68] | 2 studies · 312 participants | Moderate Downgraded: risk of bias, imprecision |
Paraesthesias High vs low stimulation | RR 0.78 [0.39, 1.53] | 2 studies · 312 participants | Moderate Downgraded: risk of bias, imprecision |
High versus low stimulation for partial seizures
Population: patients with partial seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
50% reduction in seizure frequency (responders) High vs low stimulation | RR 1.73 [1.13, 2.64] | 4 studies · 373 participants | Moderate Downgraded: risk of bias, imprecision |
Withdrawals High vs low stimulation | RR 2.56 [0.51, 12.71] | 4 studies · 375 participants | Low Downgraded: risk of bias, imprecision |
Voice Alteration or Hoarseness High vs low stimulation | RR 2.17 [1.49, 3.17] | 3 studies · 330 participants | Moderate Downgraded: risk of bias, imprecision |
Cough High vs low stimulation | RR 1.09 [0.74, 1.62] | 3 studies · 334 participants | Moderate Downgraded: risk of bias, imprecision |
Dyspnea High vs low stimulation | RR 2.45 [1.07, 5.6] | 2 studies · 312 participants | Low Downgraded: risk of bias, imprecision |
Pain High vs low stimulation | RR 1.01 [0.6, 1.68] | 2 studies · 312 participants | Moderate Downgraded: risk of bias, imprecision |
Paresthesias High vs low stimulation | RR 0.78 [0.39, 1.53] | 2 studies · 312 participants | Moderate Downgraded: risk of bias, imprecision |