Cochrane · systematic review · CD002878
Chronic non‐invasive ventilation for chronic obstructive pulmonary disease
Raveling, T, Vonk, J, Struik, FM, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
17
current version
GRADE rated
17
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 29.4%Low 6 · 35.3%Moderate 3 · 17.6%High 3 · 17.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlySummary of Findings Table ‐ Chronic non‐invasive ventilation compared to standard treatment for people with stable COPD
Population: stable COPD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in arterial partial pressure of oxygen Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment | no estimate extracted | 9 studies · 271 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Change in arterial partial pressure of oxygen Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment | no estimate extracted | 3 studies · 171 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Change in arterial partial pressure of carbon dioxide Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment | no estimate extracted | 11 studies · 475 participants | High |
Change in arterial partial pressure of carbon dioxide Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment | no estimate extracted | 4 studies · 232 participants | High |
Change in 6‐minute walking distance Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment | no estimate extracted | 8 studies · 330 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Change in 6‐minute walking distance Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment | no estimate extracted | 3 studies · 134 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Change in the health‐related quality of life Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment | no estimate extracted | 5 studies · 259 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Change in the health‐related quality of life Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment | no estimate extracted | 4 studies · 200 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
All‐cause mortality Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment | HR 0.75 [0.58, 0.97] | 3 studies · 405 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Summary of Findings Table ‐ Chronic non‐invasive ventilation compared to standard treatment following a severe exacerbation for people with severe COPD
Population: post‐exacerbation COPD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in arterial partial pressure of oxygen Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment following a severe exacerbation | no estimate extracted | 3 studies · 234 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Change in arterial partial pressure of oxygen Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment following a severe exacerbation | no estimate extracted | 3 studies · 170 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Change in arterial partial pressure of carbon dioxide Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment following a severe exacerbation | no estimate extracted | 3 studies · 241 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Change in arterial partial pressure of carbon dioxide Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment following a severe exacerbation | no estimate extracted | 3 studies · 175 participants | High |
Change in the health‐related quality of life Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment following a severe exacerbation | no estimate extracted | 2 studies · 219 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Change in the health‐related quality of life Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment following a severe exacerbation | no estimate extracted | 2 studies · 164 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Admission‐free survival Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment following a severe exacerbation | HR 0.71 [0.54, 0.94] | 2 studies · 317 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
All‐cause mortality Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment following a severe exacerbation | HR 0.97 [0.74, 1.28] | 2 studies · 318 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Nocturnal non‐invasive positive pressure ventilation compared with standard treatment for severe COPD
Population: adults with severe COPD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Arterial blood gas tension: PaO2 after 3 months mmHg Nocturnal non‐invasive positive pressure ventilation vs standard treatment | no estimate extracted | 6 studies · 162 participants | Moderate |
Arterial blood gas tension: PaCO2 after 3 months mmHg Nocturnal non‐invasive positive pressure ventilation vs standard treatment | no estimate extracted | 6 studies · 162 participants | Moderate |
6MWD after 3 months metres Nocturnal non‐invasive positive pressure ventilation vs standard treatment | no estimate extracted | 3 studies · 40 participants | Low |
Quality of life: SGQR after 12 months total score on a scale from 0 to 100 Nocturnal non‐invasive positive pressure ventilation vs standard treatment | no estimate extracted | 2 studies · 103 participants | Low |
Lung function: FEV1 after 3 months litres Nocturnal non‐invasive positive pressure ventilation vs standard treatment | no estimate extracted | 5 studies · 83 participants | Low |